Update on histopathological evaluation of lymphadenectomy specimens from prostate cancer patients |
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| Authors: | Alessandro?Conti Matteo?Santoni Luciano?Burattini Marina?Scarpelli Roberta?Mazzucchelli Andrea?B?Galosi Liang?Cheng Antonio?Lopez-Beltran Alberto?Briganti Francesco?Montorsi Email author" target="_blank">Rodolfo?MontironiEmail author |
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| Institution: | 1.Department of Odontostomatologic and Specialized Clinical Sciences, Section of Urology,Marche Polytechnic University, School of Medicine,Ancona,Italy;2.Medical Oncology,Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I, GM Lancisi, G Salesi,Ancona,Italy;3.Section of Pathological Anatomy,Marche Polytechnic University, School of Medicine, AOU Ospedali Riuniti,Torrette, Ancona,Italy;4.Department of Pathology and Laboratory Medicine,Indiana University School of Medicine,Indianapolis,USA;5.Department of Surgery,Cordoba University Medical School,Cordoba,Spain;6.Unit of Urology/Division of Oncology,URI, IRCCS Ospedale San Raffaele,Milan,Italy |
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| Abstract: | BackgroundMetastases to lymph nodes (LNs) represent an unfavorable prognostic factor in patients with prostate cancer (PCa). Histological examination represents the gold standard in the evaluation of the lymphadenectomy (LND) specimens for the presence of secondary deposits.Methods and resultsThe metastatic detection rate can vary according to the approach adopted in the microscopic analysis of the LNs, which includes frozen-section examination, total inclusion of the tissue with and without whole-mount sections, serial sectioning, and the application of immunohistochemistry. The assessment of the sentinel LN, the search for micrometastases, and the evaluation of atypical LN metastatic sites further contribute to the detection of the metastatic spread.ConclusionIn this review, an update on the histopathological evaluation of LND specimens in patients with PCa is given, and focus is made on their clinical and prognostic significance. |
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