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Sterile inflammatory responses mediated by the NLRP3 inflammasome |
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| Authors: | Suzanne L. Cassel Fayyaz S. Sutterwala |
| Affiliation: | 1. Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA;2. Inflammation Program, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA;3. Division of Infectious Diseases, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA |
| Abstract: | Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non‐microbial insults causes the activation of nucleotide‐binding domain leucine‐rich repeat containing receptors in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses. |
| Keywords: | Caspase‐1 Danger signals Necrosis |