老年急性脑梗死患者同型半胱氨酸与预后的关系

目的:探讨老年急性脑梗死患者同型半胱氨酸水平与预后的关系。方法:选择80例老年急性脑梗死患者作为观察组,同期选取60例健康体检者为对照组。采用循环酶法测定血浆同型半胱氨酸水平,乳胶增强免疫比浊法测定高敏C-反应蛋白(hs-CRP),比较两组血清同型半胱氨酸、hs-CRP水平以及二者与脑梗死患者病情严重程度的关系。结果:观察组血清同型半胱氨酸、hs-CRP水平明显高于对照组,差异有统计学意义(P<0.01);观察组轻型、中型及重型脑梗死组患者同型半胱氨酸、hs-CRP水平逐渐升高,差异有统计学意义(P<0.05)。结论:老年急性脑梗死患者血清同型半胱氨酸、hs-CRP水平显著升高,且与患者病情相关,表明二者参与了动脉粥样硬化形成发展过程,二者联合检测可作为判断患者预后的重要指标。

Relation of homocysteine and prognosis of elder acute cerebral infarction

Objective: To explore the relation of homocysteine and prognosis of elder acute cerebral infarction.Methods:A total of 80 elder cases with acute cerebral infarction were selected as experiment group,and 60 healthy persons as controls.Cyclophorase was used to detect homocysteine and immunoturbidimetry was performed to detect C-reaction protein(hs-CRP).The level of homocysteine and hs-CRP of two groups and the relation of homocysteine and severity were studied.Results:Serum levels of homocysteine and hs-CRP in experiment group were significantly higher than those in control group(P<0.01);Homocysteine and hs-CRP levels were significantly higher in severe group than medium group and mild group(P<0.05).Conclusions:Homocysteine and hs-CRP levels greatly increase in elder acute cerebral infarction and have a relation with severity.They participate in the progress of atherogenesis and can be important index for predicting the prognosis.