博司捷治疗新生儿缺氧缺血性脑病86例临床观察

目的:观察博司捷(注射用单唾液酸四己糖神经节苷脂钠)治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法:将我院2008年1月～2010年1月间收治的HIE患儿166例随机分为两组,观察组86例,对照组80例。观察组患儿采用HIE常规治疗的基础上加用博司捷治疗,对照组在HIE常规治疗的基础上联合胞二磷胆碱治疗,比较两组的疗效及NBNA评分。结果:观察组、对照组总有效率分别为93.0%、72.5%,差异有统计学意义(P<0.05),两组中度脑损害患者总有效率比较差异有统计学意义(P<0.05),轻度及重度脑损害比较差异无统计学意义(P>0.05)。两组患儿治疗前NBNA评分差异无统计学意义(t=0.125,P>0.05);观察组治疗后14、28dNBNA评分优于对照组,组间比较差异均有统计学意义(t分别为2.82、4.36,P均<0.01)。结论:博司捷治疗新生儿缺氧缺血性脑病临床疗效确切,可有效改善神经功能症状,减轻后遗症,值得儿科临床推广应用。

Effect of Ganglioside GM1 on neonatal hypoxic ischemic encephalopathy

Objective: To observe the clinical effects of ganglioside GM1 in the treatment of neonatal hypoxic ischemic encephalopathy(HIE).Methods:A total of 166 neonates with HIE admitted in our hospital from January 2008 to January 2010 were divided into treatment group(n=86) and control group(n=80) randomly.The treatment group was treated with GM1 on the basis of conventional therapy,while the control group was treated with citicoline together with conventional therapy for HIE.The efficacy and neonatal behavioral neurological assessment(NBNA) scores of two groups were compared.Results:The total efficacy was 93.0% and 72.5% in treatment group and control group,with significant difference between two groups(P<0.05).There was no significant difference in total efficacy or NBNA score between patients with mild cerebral injury and severe injury patients(P>0.05).There was no significant difference NBNA score between treatment group and control group before treatment(t=0.125,P>0.05).Patients in treatment group had higher score than control group 14 and 28 d later,with significant difference between two groups(t=2.82,4.36,both P<0.01).Conclusions:Ganglioside GM1 is effective in the treatment of Neonatal HIE.It can improve neurological symptoms and relieve sequela.Thus,it’s worthy of clinical application in department of pediatrics.