血液灌流联合血液透析治疗尿毒症的临床疗效

目的:探讨血流灌流串联血液透析治疗尿毒症的临床疗效。方法:将我院收治的顽固型尿毒症患者76例随机分为研究组和对照组,每组38例,研究组患者采用血液灌流串联血液透析治疗,每周2次;对照组患者采用常规血液透析治疗。观察治疗前、后两组患者高血压、皮肤瘙痒、贫血等症状改善情况;并比较两组患者血液中肌酐(Cr)、血尿素氮(BUN)、中分子物质(MMS)、甲状旁腺素(PTH)等水平。结果:(1)治疗后两组患者血压明显降低,皮肤瘙痒程度有所减轻,血红蛋白和红细胞压积有所升高;但研究组上述指标改善情况明显好于对照组(P<0.05)。(2)治疗后两组患者Cr、BUN、MMS、PTH水平明显降低,但研究组下降水平明显大于对照组(P<0.05)。结论:血液灌流串联血液透析能有效清除慢性尿毒症患者体内中分子物质、甲状旁腺素和其他有毒物质,对于治疗尿毒症有较好临床疗效。

Clinical efficacy of hemoperfusion combing with hemodialysis for uremia

Objective: To investigate the clinical efficacy of hemoperfusion combing with hemodialysis for uremia.Methods:A total of 76 patients with uremia were randomly divided into study group and control group with 38 cases in each group.The study group was treated with hemoperfusion and hemodialysis,twice a week;while the control group was treated with conventional hemodialysis.Improvements in hypertension,itching skin,anemia and other symptoms,as well as serum creatinine(Cr),urea nitrogen(BUN),middle molecular substances(MMS),parathyroid hormone(PTH) levels were observed and compared between the two groups.Results:After treatment,both groups showed improvements in blood pressure,itching skin,and increased hemoglobin and hematocrit;but the improvements in the study group was more significantly than that of the control group(P<0.05).After treatment,Cr,BUN,MMS,PTH levels were significantly decreased in both groups,but the decrease was more obviously in the study group(P<0.05).Conclusions:Hemoperfusion combing with hemodialysis can effectively remove parathyroid hormone and other toxic substances,thus show good clinical efficacy on uremia.