卵巢癌患者术后早期血清CA125、CEA和TSGF的动态监测

目的:研究上皮性卵巢癌(EOC)患者经手术治疗后机体糖类抗原CA125、癌胚抗原(CEA)、恶性肿瘤相关物质群(TSGF)变化情况,初步探讨其联合检测在疗效预测及预后判断中的临床价值。方法:选取健康对照71例(正常对照组)及我院住院卵巢上皮癌患者71例(卵巢癌组),分别检测其术前、术后静脉血中CA125、CEA和TSGF水平,并对检测结果进行比较。结果:卵巢癌组患者术前血清TSGF、CA125、CEA水平均高于正常对照组,差异有统计学意义(P<0.05～0.01)。同术前比较,卵巢癌患者术后7、15、30dCA125、CEA和TSGF水平变化明显(P<0.05～0.01),CA125和CEA在术后30d左右接近正常水平,TSGF在术后15d左右接近正常。结论:手术前、后动态监测EOC患者血清CA125、CEA和TSGF的变化情况,有助于判断疗效,监测复发或转移。

Dynamic determinations of early changes of serum CA125, CEA and TSGF in patients with EOC after surgery

Objective: To investigate the dynamic change of serum CA125,CEA and TSGF in patients with EOC,and their diagnosis value.Methods:A total of 71 healthy adults and 71 patients with EOC were selected.Serum concentrations of CA125,CEA and TSGF were measured and compared before and after surgery.Results:The results showed that the concentrations of CA125,CEA and TSGF in pre-operative EOC patients were significantly increased(P<0.05-0.01).The levels of serum CA125 and CEA decreased gradually in patients with EOC after surgery and returned to the normal level about 30 days after operation,while the concentration of serum TSGF completely returned to the normal about 15 days after operation.Conclusions:The combined detection of the pre-and post-operative dynamic changes of serum CA125,CEA and TSGF in patients with EOC was useful in diagnosis,treatment evaluation and prognosis monitoring.