米索前列醇预防产后出血的临床及护理分析

目的:探讨临床应用米索前列醇预防产后出血的效果。方法:选取我科2009年7月～2010年12月间住院并经阴道正常分娩的产妇400例,随机分为米索组132例、米索+缩宫素组142例及缩宫素组126例,三组患者临床资料比较无明显统计学差异。3组给药时间均为胎儿娩出后,米索组胎儿娩出后立即口服米索前列醇400μg;米索+缩宫素组胎儿娩出后立即静脉滴注缩宫素20U并口服米索前列醇400μg,缩宫素组胎儿娩出后立即静脉滴注缩宫素20U。临床观察3组分娩后2h内阴道出血量。结果:观察3组患者产后2h内阴道平均出血量,米索组为(280±46)mL;米索+缩宫素组为(216±45)mL;缩宫素组为(360±49)mL;组间比较差异显著,以米索+缩宫素组最优,米索组次之,缩宫素产后出血发生率最高。比较差异具有统计学意义(P<0.01)。结论:米索前列醇可促进子宫收缩,作用强于缩宫素,能较好的预防产后出血,且用药方便、安全,值得临床推广应用。

Clinical analysis of misoprostol for prevention of postpartum hemorrhage

Objective: To investigate the clinical effects of misoprostol for preventing postpartum hemorrhage.Methods:In this study,A total of 400 puerpera scheduled for vaginal delivery in the Department of Obstetrics of our hospital during July 2009 and December 2010 were enrolled and randomly divided into 3 groups.Treatments were all given immediately after the fetus was delivered.For the misoprostol group,oral administration of 400μg misoprostol;for oxytocin + misoprostol group,oral administration of 400μg misoprostol + intravenous drip of 20U oxytocin was given,while the oxytocin group was only given intravenous drip of 20U oxytocin.Average amount of bleeding 2 h post-partum of the three groups were observed and compared.Results:Average amount of bleeding 2 h post-partum of the three groups were listed as following: misoprostol group,(280±46)mL;oxytocin + misoprostol group,(216±45)mL;oxytocin group,(360±49)mL;indicating significant better prevention effects in oxytocin + misoprostol group comparing with that in other two groups.Oxytocin group showed the highest incidence of post-partum bleeding(P<0.01).Conclusions:Misoprostol can promote stronger uterine contractions than oxytocin,thus has good prevention effects for post-partum bleeding.