重症急性胰腺炎合并腹腔感染的病原菌特点与治疗分析

目的:分析重症急性胰腺炎(SAP)患者合并腹腔感染的病原菌特点及治疗模式,为临床救治提供参考.方法:收集2018年1月-2020年12月我院收治的127例SAP患者资料,其中感染组病例40例.分析患者合并腹腔感染病原菌种类、耐药性、经验性抗生素使用等资料.结果:SAP伴发腹腔感染以两种及其以上细菌、真菌混合感染为主,其...

Pathogenic characteristics and treatment of severe acute pancreatitis complicated with abdominal infection

Objective: To analyze the characteristics and treatment of abdominal infection in patients with severe acute pancreatitis(SAP), and to provide reference for clinical treatment. Methods: Data of 127 SAP patients admitted to our hospital from January 2018 to December 2020 were collected, including 40 cases in the infection group. The types of pathogenic bacteria, drug resistance and empirical antibiotic use of patients with abdominal infection were analyzed. Results: The peritoneal infection of severe acute pancreatitis was mainly caused by the mixed infection of two or more bacteria and fungi, in which the proportion of multiple or even full drug resistant Gram-negative bacilli and invasive fungi was increasing. Based on the clearance of infected necrotic tissue and the results of dynamic pathogen culture, the selection of carbapenems, vancomycin and antifungal drugs increased. Ceftazidime-avibatam was also increasingly used against superbugs. Conclusion: SAP patients with abdominal infection have complex pathogens and high drug resistance rate. The distribution of main pathogens and drug sensitivity results both are very important. Dynamic samples of patients should be sent to ensure the effectiveness and safety of clinical medication.