糖尿病性视网膜病变患者常规全视网膜光凝后黄斑中心凹下脉络膜厚度变化的荟萃分析

目的 通过荟萃分析系统评价糖尿病性视网膜病变(DR)患者在常规全视网膜光凝(PRP)后黄斑中心凹下脉络膜厚度(SFCT)的变化.方法 检索PubMed、EM-BASE、Web of Science及Cochrane Library英文数据库和万方数据知识服务平台、维普中文期刊服务平台及中国知网中文数据库,搜集行PRP术...

A meta-analysis of changes in the subfoveal choroidal thickness in diabetic retinopathy patients after conventional panretinal photocoagulation

Objective To evaluate the changes in the subfoveal choroidal thickness(SFCT)in diabetic retinopathy(DR)patients after conventional panretinal photocoagulation(PRP)using a meta-analysis system.Methods By searching PubMed,EMBASE,Web of Science and Cochrane Library English databases,Wanfang Data Knowledge Service Platform,VIP Chinese Journal Service Platform,and CNKI Chinese Database,two researchers collected literature studying the SFCT of DR patients at different times post PRP.The two researchers independently performed paper search,screening,quality evaluation,and data extraction,and used pooled weighted mean differences(WMD)and 95%confidence interval(CI)as statistical data.Q and I² tests were used to evaluate the heterogeneity among different studies,with P<0.05 or I²>50%indicating large heterogeneity.Sensitivity analysis was used to exclude studies with large bias or with a high risk of bias,and then the stability of the combined results was checked.If the exclusion did not significantly reduce heterogeneity,the random effects model was used for analysis.Results A preliminary search in the above databases initially obtained 141 relevant studies.After screening based on inclusion and exclusion criteria,11 studies that investigated a total of 401 eyes were eventually included in the meta-analysis.Considering that the sample size of the included studies was relatively small,the random effects model was preferred regardless of I² value.As shown by the random effects model analysis,one week after PRP,the combined WMD showed a significant increase in SFCT(WMD=-18.012;95%CI31.905,4.118;P=0.011).One month after PRP,the combined WMD showed that the SFCT was not significantly different from the baseline(WMD=10.818;95%CI-0.993,22.630,P=0.073).Three and six months after PRP,the combined WMD showed a significant decrease in SFCT(three monthsWMD=15.973;95%CI5.610,26.336,P=0.003.Six monthsWMD=18.249;95%CI0.560,35.939,P=0.043).Conclusion After PRP,DR patients will have increased SFCT first,which then gradually decreases over time and becomes significantly lower than the baseline after three months.