血脂、同型半胱氨酸与帕金森病合并认知障碍相关性

目的 探讨血脂、同型半胱氨酸(Hcy)水平与帕金森病(PD)合并认知障碍程度的相关性。方法 收集2019年9月至2021年8月在锦州市中心医院神经内科就诊PD患者100例以及健康体检者50例分别纳入PD组和对照组,PD组根据蒙特利尔认知评价量表(MoCA)评分分为PD认知正常(PD-NC)亚组38例、PD轻度认知障碍(PD-MCI)亚组32例和PD痴呆(PDD)亚组30例。检测所有患者血脂和血清Hcy水平,探究组间指标差异,并分析以上指标与认知障碍程度的相关性。结果 PD组Hcy水平显著高于对照组(P<0.05),总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平低于对照组(P<0.05)。PD-NC亚组、PD-MCI亚组及PDD亚组的TG、LDL-C、Hcy水平差异有统计学意义(P<0.05),Logistic回归分析显示Hcy是PD认知障碍的独立危险因素(P<0.05)。结论 PD患者TG、LDL-C、Hcy水平与其认知障碍程度有一定的相关性。

Correlation between blood lipid and homocysteine and cognitive impairment in Parkinson's disease

Objective To investigate the correlation between the levels of blood lipid and homocysteine(Hcy)and the degree of cognitive impairment in Parkinson's disease(PD).Methods A total of 100 PD patients and 50 healthy people admitted to the Department of Neurology of Jinzhou Central Hospital during Sept 2019-Aug 2021 were respectively registered into PD group and control group.According to the score of Montreal cognitive Assessment(MoCA),patients in PD group were divided into 38 patients with normal cognition(PD-NC),32 patients with mild cognitive impairment(PD-MCI)and 30 patients with PD dementia(PDD).The aim was to detect levels of blood lipid and serum Hcy of all patients,explore the differences of indicators between groups,and analyze the correlation between the above indicators and the degree of cognitive impairment.Results Compared with control group,PD group had significantly higher level of Hcy(P<0.05),lower levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)(P<0.05),significant differences existed in the levels of TG,LDL-C and Hcy among PD-NC subgroup,PD-MCI subgroup and PDD subgroup(P<0.05).Logistic regression analysis showed that Hcy was an independent risk factor for PD cognitive impairment(P<0.05).Conclusion There is a certain correlation between the levels of TG,LDL-C and Hcy and the degree of cognitive impairment for PD patients.