| 碘过量和硒对EAT大鼠血脂水平影响 |
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| 引用本文： | 张锦香,桑仲娜,谭龙,姚斋潇,吴蕴棠,张万起.碘过量和硒对EAT大鼠血脂水平影响[J].中国公共卫生,2010,26(3). |
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| 作者姓名： | 张锦香 桑仲娜 谭龙 姚斋潇 吴蕴棠 张万起 |
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| 作者单位： | 天津医科大学公共卫生学院营养与食品卫生教研室,天津,300070 |
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| 摘 要： | 目的探讨碘过量对实验性自身免疫性甲状腺炎(Experiment autoimmune thyroiditis,EAT)大鼠血脂的影响及不同硒水平的干预作用。方法雌性Lewis大鼠随机分为对照、造模、造模+高碘补硒、造模+高碘适硒、造模+高碘低硒组。猪甲状腺球蛋白免疫建立EAT模型。检查大鼠甲状腺病理改变,测定各组甲状腺自身抗体、甲状腺激素及血脂水平。结果各组甲状腺自身抗体及甲状腺激素水平均明显高于对照组;造模组甘油三酯(TG)水平(1.09±0.29)mmol/L明显低于对照组(1.93±0.59)mmol/L,高密度脂蛋白胆固醇(HDL-C)水平(1.23±0.12)mmol/L则明显高于对照组(0.93±0.21)mmol/L;造模+高碘适硒组总胆固醇(TC)水平(2.36±0.24)mmol/L及低密度脂蛋白胆固醇(LDL-C)水平(0.92±0.21)mmol/L均明显低于造模组(2.87±0.10),(1.42±0.15)mmol/L;相同高碘水平下,血脂水平随着补硒量的减少呈上升趋势。结论大鼠在EAT及碘过量伴EAT时有血脂代谢紊乱,相同高碘水平下低硒时加重甲状腺的炎症破坏并伴有血脂的升高。
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| 关 键 词： | 碘 自身免疫性甲状腺炎 硒 血脂 |
Effects of chronic iodine excess and selenium on serum lipid of EAT rats |
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| ZHANG Jin-xiang,SANG Zhong-na,TAN Long,et al..Effects of chronic iodine excess and selenium on serum lipid of EAT rats[J].Chinese Journal of Public Health,2010,26(3). |
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| Authors: | ZHANG Jin-xiang SANG Zhong-na TAN Long |
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| Institution: | ZHANG Jin-xiang,SANG Zhong-na,TAN Long,et al.Department of Nutrition , Food Hygiene,School of Public Health,Tianjin Medical University(Tianjin 300070,China) |
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| Abstract: | Objective To research the effects of iodine excess on serum lipid of rats with experiment autoimmune thyroiditis(EAT) and the interventive effect of different concentrations of selenium.Methods Female Lewis rats were divided into five groups at random:control group,model group,model and excess iodine plus selenium group,model and excess iodine group,model and excess iodine plus low selenium group.The rats were immuned with pig thyroglobulin to establish EAT model.The pathological changes of thyroid gland we... |
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| Keywords: | iodine EAT selenium serum lipid |
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