| CYP450氧化还原酶遗传多态性对CYP酶影响的研究进展 |
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| 引用本文： | 黄路,阳国平. CYP450氧化还原酶遗传多态性对CYP酶影响的研究进展[J]. 中国临床药理学与治疗学, 2013, 18(7): 818-823 |
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| 作者姓名： | 黄路 阳国平 |
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| 作者单位： | 中南大学药学院,长沙410013,湖南;中南大学湘雅三医院,长沙410013,湖南 |
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| 摘 要： | 细胞色素P450氧化还原酶(Cytochrome P450 0xidoreductase,POR)是将电子从NADPH转运至所有肝微粒体的细胞色素P450氧化酶(Cytochrome P450 monooxygenases,CYP)中的唯一供体.药物、类固醇激素等物质的代谢和转化需要CYP参与.POR基因具有遗传多态性,遗传变异可以改变CYP活性,引起P450氧化还原酶缺陷(P450 0xidoreductase deficiency,PORD)、临床药物代谢和反应差异.本文将从POR的结构功能、基因突变引起的疾病及其对酶活性影响三个方面进行论述,总结近年来POR遗传多态性对CYP酶影响的最新研究进展.
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| 关 键 词： | CYP450氧化还原酶 细胞色素P450氧化酶 P450氧化还原酶缺陷 遗传多态 基因突变 |
Progress on influence of cytochrome P450 oxidoreductase polymor-phisms on cytochrome P450 monoxyfenases |
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| HUANG Lu,YANG Guo-ping. Progress on influence of cytochrome P450 oxidoreductase polymor-phisms on cytochrome P450 monoxyfenases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(7): 818-823 |
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| Authors: | HUANG Lu YANG Guo-ping |
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| Affiliation: | 1 The Pharmacy College of Central South University, Changsha 410013, Hunan, China; 2 The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan,China) |
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| Abstract: | Cytochrome P450 oxidoreductase （POR） is the only electron dornor for transferring electrons from NADPH to all microsome Cytochrome P450 monooxygenases（CYP）.CYP is involved in the metabolism and transformation of drugs ,steroids and other substances. Polymorphisms and genetic variations of POR change the activity of CYP, resulting in P450 oxidoreductase deficiency （PORD）, differences on drug metabolism and reaction. The review summarizes the recent research progress on influence of POR genetic polymorphisms on CYP from three parts： structure and function, disease and influence on enzymes. |
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| Keywords: | Cytochrome P450 oxidoreduc-tase Cytochrome P450 monooxygenases P450oxidoreduetase deficiency~ Genetic polymor-phism Genetic variation |
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