ALT单项不合格献血者再次献血血液筛查结果追踪调查分析

目的探讨和评价ALT血液筛查项目在临床用血血液安全中的意义。方法采用回顾性调查法对2010年10月至2012年12月期间,ALT单项阳性并再次献血的献血者血液筛查结果进行追踪调查和分析。结果 3910例再次献血者中,HBsAg、抗-HCV、抗-HIV、抗-TP以及ALT血液筛查结果均合格3053例,占再次献血的78.1%,ALT单项仍为阳性845例,占不合格的98.6%（845/857）,ALT阴性而ELISA筛查项目阳性9例,核酸筛查阳性3例,其中ALT合并NAT阳性1例。结论 ALT血液筛查在肝炎病毒感染＂窗口期＂或隐匿性感染中有提示的作用,在一定程度上能减少漏检的发生,在保障血液安全中具有一定的意义。

Significance of ALT screening in the safety of blood donation by the ALT deferred donors

Objective To investigate and evaluate the significance of ALT screening in the safety of blood donation. Methods The blood screening results of ALT deferred donors （October 2010 to December 2012） from the Guangzhou Blood Center were investigated and analyzed by retrospective survey method. Results Among the 3 910 2nd time blood donors with previous unqualified ALT, 3 053 （78.1%） donors were found to have qualified results in the testing of HBsAg, anti-HCV, anti-HIV, anti-TP and ALT screening. 845（98.6%） were found to have unqualified result with ALT screening only. Other 11 were found to have unqualified results in either ELISA or NAT, while their ALT screening result was qualified. One donor was found to have unqualified result with both ALT and NAT. Conclusion ALT screening can play a role in the monitoring of hepatitis virus infection and in reducing the risk of transmission due to the window-period and other occult infections.