血管紧张素原M235T多态性与神经胶质瘤的关系

目的 探讨血管紧张素原基因(AGT)甲硫氨酸235苏氨酸(M235T)多态性在神经胶质瘤患者和正常对照人群中的分布及与神经胶质瘤的相关性.方法 采用聚合酶链反应-限制性片段长度多态性检测135例神经胶质瘤患者和181例健康对照组AGT M235T多态性.结果 与苏氨酸/苏氨酸(TT)基因型相比,甲硫氨酸/苏氨酸(MT)和甲硫氨酸/苏氨酸+甲硫氨酸/甲硫氨酸(MT/MM)基因型显著增加了神经胶质瘤的发病风险(P =0.045和0.02).与T等位基因相比,M等位基因显著增加了神经胶质瘤的发病风险(P =0.019).根据性别进行亚组分析,发现MT/TT基因型在男性神经胶质瘤中的分布为57.1％,明显高于其在正常对照组男性中的分布(40.2％),差异具有统计学意义(P=0.026).结论 AGT M235T多态性与神经胶质瘤的发病具有相关性.

Association. between AGT M235T polymorphism and risk of glioma

Objective To investigate the distribution of angiotensinogen （AGT） methionine 235 threonine （M235T） in patients with glionm and healthy controls and its correlation with glioma. Methods The AGT M235T polymorphism was genotyped in 135 patients with glioma and 181 healthy controls using polymerase chain reaction- restriction fragment length polymorphism assay. Results The methionine/threonine （MT） and methionine/threonine ＋methionine/naethionine （MT/MM） genotypes were associated with the increased risks of glioma compared with threonine/threonine （TT） genotype （P =0.045, and 0.02, respectively）. Similarly, individuals Carrying the M allele had a significantly increased risk of developing glioma compared with those carrying the T allele （P =0.019）. When stratified according to gender, the percentage of the MT/TT genotype in male patients with glioma was 57.1%, which was higher than that in male healthy controls （P =0.026）. Conclusion AGT M235T pelymorphism may be related to the development of glioma.