硒、维生素E联用对高胆固醇血症家兔血液流变性的影响

对高胆固醇血症家兔应用硒（Ｓｅ）、维生素Ｅ（ＶＥ）前后血液流变性、过氧化脂质（ＬＰＯ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）和超氧化物歧化酶（ＳＯＤ）、血栓素（ＴＸＡ２）、前列环素（ＰＧＩ２）进行观察。发现Ｓｅ或ＶＥ及Ｓｅ、ＶＥ联用可不同程度降低高胆固醇家兔红细胞压积和红细胞聚集性，增加红细胞变形性，降低血清ＬＰＯ含量、ＴＸＡ２／ＰＧＩ２比值和ＴＸＡ２水平，提高ＧＳＨ－Ｐｘ、ＳＯＤ活力和ＰＧＩ２水平。提示Ｓｅ和ＶＥ有降低血液粘稠度作用，Ｓｅ、ＶＥ联用组效果优于Ｓｅ或ＶＥ单用组。

Effects of Selenium and Vitamin E Combination on Hemorheological Property in Rabbits with Hyper-cholestorolemia

Changes of hemorheological property, lipid peroxides concentration, thromboxane A(TXA2) and prostacylin(PGI2) levels, glutahione peroxidase and superoxide dismutase activities in rabbits with hypercholestorolemia were observed by using selenium or/and vitamin E. The results showed that hemotocrit and erythrocyte aggregation were reduced, and erythrocyte deformability was increased in different degrees in rabbits on selenium or/and vitamin E administration. Simultaneously, concentration of lipid peroxides, level of TXA2 were reduced, activities of glutathione peroxidase and superoxide dismutase, level of PGI2 were significantly enhanced. The study suggested that selemium and vitamin E have a decreased effect on blood viscosity. Combination of the both components selenium and vitamin E is more effective than separate application. 