| 补阳还五汤对沙土鼠脑缺血再灌注星形胶质细胞的影响 |
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| 引用本文： | 赖真,王沙燕,耿小茵,邓常青,张阮章.补阳还五汤对沙土鼠脑缺血再灌注星形胶质细胞的影响[J].中国中药杂志,2002,27(10):763-765. |
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| 作者姓名： | 赖真 王沙燕 耿小茵 邓常青 张阮章 |
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| 作者单位： | 1. 暨南大学医学院,附属第二医院,深圳市人民医院,广东,深圳,518020
2. 广州中医药大学,糖尿病研究所,广东,广州,510405 |
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| 基金项目： | 广东省中医药管理局科研项目 (99617) |
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| 摘 要： | 目的 :探讨补阳还五汤对脑缺血再灌注后星形胶质细胞 (AS)的影响。方法 :采用沙土鼠双侧颈动脉夹闭脑缺血模型 ,于脑缺血 15min、再灌注24h和48h后 ,运用免疫组织化学技术观察星型胶质纤维酸性蛋白(GFAP)的动态表达。结果 :缺血 15min再灌注 24h后 ,GFAP免疫阳性反应达高峰 ,补阳还五汤可使GFAP免疫反应减轻 ;缺血 15min再灌注 48h后GFAP表达减弱 ,补阳还五汤可使其增强。结论 :补阳还五汤对脑缺血再灌注后星形胶质细胞的调节作用可能与脑缺血损伤后神经功能的恢复有关。
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| 关 键 词： | 补阳还五汤 脑缺血 星形胶质细胞 |
| 文章编号： | 1001-5302(2002)10-0763-03 |
| 收稿时间： | 2002/1/21 0:00:00 |
| 修稿时间： | 2002年1月21日 |
Effects of Bu Yang Huan Wu Decoction on Astrocytes after Cerebral Ischemia and Reperfusion |
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| LAI Zhen;WANG Sha-yan;GENG Xiao-yin;DENG Chang-qing;ZHANG Ruan-zhang.Effects of Bu Yang Huan Wu Decoction on Astrocytes after Cerebral Ischemia and Reperfusion[J].China Journal of Chinese Materia Medica,2002,27(10):763-765. |
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| Authors: | LAI Zhen;WANG Sha-yan;GENG Xiao-yin;DENG Chang-qing;ZHANG Ruan-zhang |
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| Institution: | Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China. |
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| Abstract: | Objective: To study the effects of Bu Yang Huan Wu Decoction on astrocytes after cerebral ischemia and reperfusion. Method:Cerebral ischemia model in gerbils was produced by ligating bilateral common carotid artery. The dynamic expressin of GFAP were determined by immunochemistry after cerebyal ischemia for 15min followed by reperfusion for 24 hours and 48 hours. Result: GFAP positive reactions reached a peak after cerebral ischemia for 15 min followed by reperfusion for 24 hours. Bu Yang Huan Wu Decoction decreased the expression. GFAP positive reactions decreased after cerebral ischemia for 15 min followed by reperfusion for 48 hours, Bu Yang Huan Wu Decoction increased the expression. Conclusion:The regulation of Bu Yang Huan Wu Decoction on astrocytes after cerebral ischemia and reperfusion may be related to repairing process after cerebral ischemia. |
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| Keywords: | Bu Yang Huan Wu Decoction brain ischemia astrocytes |
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