Comparison of integrin adhesion molecules expressed by primary brain lymphomas and nodal lymphomas |
| |
Authors: | W Paulus K Jellinger |
| |
Institution: | (1) Institute of Pathology, University of Würzburg, School of Medicine, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany;(2) Ludwig Boltzmann Institute of Clinical Neurobiology, Vienna, Austria |
| |
Abstract: | The expression of 17 adhesion molecules was immunohistochemically examined in 5 primary cerebral lymphomas (PCL) and in 5 histologically similar nodal lymphomas (NL) to evaluate their possible involvement in selective targeting of lymphoma cells to the brain. PCL and NL tumor cells showed very similar expression patterns: they were consistently positive for 3, 4 and 1 integrin chains; negative for 2, 6, 3 and 4 integrin chains; and heterogeneous for 5, L, M, X, 2 and 7 integrin chains, as well as for intercellular adhesion molecule-1 (ICAM-1) and the selectin LECAM-1. Loosely infiltrating PCL showed lower levels of the L 2 integrin than compact cell clusters. Vessels stained for ICAM-1 and vascular cell adhesion molecule-1 (VCAM-1). We conclude that the adhesion molecules implicated in the extravasation of non-neoplastic leukocytes ( 4 1/VCAM-1 and L 2/ICAM-1) are also expressed by both PCL and NL. The adhesion molecules examined are apparently not selective mediators of lymphoma cell homing to the brain, but at least L 2 integrin might be related to the infiltration pattern of PCL within the brain parenchyma.Supported by the Sander Foundation |
| |
Keywords: | Brain lymphoma Nodal lymphoma Adhesion molecules Integrins |
本文献已被 SpringerLink 等数据库收录! |
|