我院2004-2007年铜绿假单胞菌在临床感染中的分布及耐药性分析

目的探讨铜绿假单胞菌（PA）在临床感染中分布及耐药变迁，为临床合理使用抗生素提供依据。方法回顾分析2004年1月～2007年12月分离来自住院患者的所有PA分离株，药敏试验采用KB纸片扩散法。结果铜绿假单胞菌呼吸道感染最常见，占50％。其次是伤口感染占26．9％。对氨苄西林、头孢唑林、头孢呋辛的耐药率已超过80％。最敏感的药物是亚胺培南（敏感率为79．2％）。结论PA是医院感染常见条件致病菌之一，耐药现象严重。临床医师应依据药敏结果和本地区耐药情况监测，合理选择抗菌药物，可降低抗生素的耐药性。

Clinical distribution and drug resistance among 2004～2007 clinical isolate of pseudomonas aeruginosa in weng'an

Objectives： To investigate the distribution and the aeruginosa. Methods：To retrospective analysis drug resistance drug resistance of in hospital acquired infection of pseudomonas and distribution of different wards and samples of pseudomonas aeruaginosa in weng an hosptial 2004-2007, the Pseudomonas areuginosa was identified by FORTUNE.IMS2000 compact,K-B method detceted the drug resistance of pseudomonas aeruglnosa to 12 antibiotics. Results： The two foremost infection sites were respiratory tract（50%）and wound （26.9%）,more than 80% of the isolates were resistant to mpicillin,cefzolin,Cefuroxime the sensi- tivity rate of pseudomonas aeruginosa for Imipenem was 79.2%,A11 of the 178 isolates was resistant to over 3 antibiotics. Conclusions： pseudomonas areuginosa is still a major pathogenic bacteriun in our hosptial.The resistance and multiple drug re- sistance of pseudomonas areuginosa isolated from clinical samples in weng an is a serious issue.elinicans Should Select appropriate autibiotie therapy based on Sensitivity testing.The therapeutic sttalegy should be adapted.according to the local ecology of resistance and amikacin show better anti-bacterium activity.