蟾蜍灵抗癌作用机制研究进展

 蟾蜍灵是传统中药蟾酥的有效成分之一，国内外许多研究证实它对多种白血病细胞和一些实体恶性肿瘤细胞有显著抑制增殖作用，其机制可能是通过抑制内皮细胞增生和血管生成、诱导细胞分化和凋亡等实现的。随着研究的不断深入，显示蟾蜍灵具有广泛的抗肿瘤作用，其发挥效用的浓度低，具有潜在的临床应用价值。

Anti-cancer mechanism of bufalin

Bufalin is one of the major active components of Chan Su, a traditional Chinese medicine. Studies at home and abroad have confirmed that bufalin can inhibit cell proliferation significantly in many human leukemia and solid cancer cell lines by inhibiting endothelial hyperplasia and angiogenesis, and inducing cell differentiation and apoptosis. With the deepening of study，it is showed that bufalin has extensive anticancer activities and it has potential clinical value with very low drug concentration.