High prevalence of BK polyomavirus sequences in human papillomavirus-16-positive precancerous cervical lesions |
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| Authors: | Comar Manola Bonifacio Daniela Zanconati Fabrizio Di Napoli Michela Isidoro Erica Martini Fernanda Torelli Lucio Tognon Mauro |
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| Affiliation: | Institute for Maternal and Child Health, IRCCS Burlo Garofolo, and Hygiene and Preventive Medicine Unit, Department of Medical Science, University of Trieste, Trieste, Italy, Italy. |
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| Abstract: | High- and low-grade cervical lesions were analyzed for the presence of polyomavirus (PYV) and human papillomavirus (HPV) sequences. In precancerous cervical lesions, the overall prevalence of PYV sequences was 44% (41/93). Specifically, among the PYV-positive samples, 83% (34/41) tested positive for BK polyomavirus (BKV) sequences, whereas 17% (7/41) were positive for JC-virus. None of the samples were positive for simian virus 40. The presence of BKV DNA in high-grade squamous intraepithelial lesions was confirmed by in situ PCR. BKV sequences were detected more frequently in high-grade squamous intraepithelial lesions, together with the genotype HPV-16. The association of BKV with precancerous cervical lesions suggests that this polyomavirus participates with HPV-16 in the cell transformation process. Alternatively, BKV might multiply better in HPV-16-positive cells from precancerous cervical lesions than in HPV-16-negative cells. |
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| Keywords: | human papillomavirus polyomavirus cervical lesion viral load |
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