Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14) |
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Authors: | Aamot Hege Vangstein Tjønnfjord Geir E Delabie Jan Heim Sverre |
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Institution: | Department of Cancer Genetics, The Norwegian Radium Hospital, N-0310 Oslo, Norway. |
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Abstract: | We report a case of leukemic mantle cell lymphoma of the blastoid variant with complex chromosomal rearrangements leading to the recombination of BCL1 from 11q13 and IGH from 14q32. G-banding analysis showed, in addition to multiple other chromosome abnormalities, a del(11)(q13) and addition of unknown material to chromosome arms 13p and 21p. The two latter rearrangements were revealed, by use of multicolor in situ hybridization (M-FISH) analysis, to be a der(13)(qter-->p11::14q32::11q13-->11q22::14q32-->14q11::11q22-->11qter) and a similar der(21)(qter-->p11::14q32::11q13-->11q23::14q32-->14q11::11q22-->11qter). FISH with locus-specific probes for BCL1 and IGH showed a fusion signal on both derivative chromosomes. |
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