Anxiolytic-like effects of acute and chronic GABA transporter inhibition in rats |
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Authors: | Schmitt U Lüddens H Hiemke C |
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Affiliation: | (1) Department of Psychiatry, University of Mainz, Mainz, Federal Republic of Germany, DE |
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Abstract: | Summary. Acute GABA transporter inhibition can induce anxiolytic-like behaviors. The present analysis addressed whether chronic treatment (23 days via drinking water) with a GABA transporter inhibitor affects rat behavior similar to acute treatment and interferes with additional benzodiazepine-receptor agonistic treatment. Seventy-one rats divided into seven groups were acutely treated with either vehicle, diazepam (2 mg/kg), zolpidem (0.05 mg/kg), tiagabine (19 mg/kg) or chronically with tiagabine with or without acute diazepam or zolpidem. Animals were behaviorally characterized in an elevated plus-maze. None of the treatments induced changes in the activity of the animals. Acute and chronic treatment with tiagabine induced anxiolytic-like effects, similar to acute doses of diazepam. Acute diazepam did not enhance chronic tiagabine effects, whereas acute zolpidem attenuated the anxiolytic-like effects of chronic tiagabine. It is concluded that anxiolytic effects of acute GABA-uptake inhibition by tiagabine persist under chronic treatment and are sensitive to concomitant use of benzodiazepine receptor ligands. Received October 26, 2001; accepted January 30, 2002 |
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Keywords: | : GABA transporter (GAT) benzodiazepines tiagabine chronic treatment elevated plus-maze. |
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