Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation. |
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Authors: | Ioannis U Isaias Riccardo Benti Stefano Goldwurm Michela Zini Roberto Cilia Paolo Gerundini Alessio Di Fonzo Vincenzo Bonifati Gianni Pezzoli Angelo Antonini |
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Affiliation: | Centro Parkinson, Istituti Clinici di Perfezionamento, Milan, Italy. |
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Abstract: | We measured striatal dopamine transporter binding using [(123)I]ioflupane and SPECT in patients with Parkinson's disease associated with the LRRK2 (PARK8) Gly2019Ser gene mutation (LRRK2-PD) and in gene-negative patients with idiopathic Parkinson's disease (IPD) of comparable disease duration and severity. The LRRK2-PD group consisted of a total of 10 patients (3 sporadic) with mean age 62 +/- 14 years, disease duration 9 +/- 3 years, and UPDRS III motor score 21.60 +/- 6.65. The control IPD group consisted of 15 patients with mean age 59 +/- 9 years, disease duration 9 +/- 5 years, and UPDRS III motor score 23.80 +/- 8.69. [(123)I]ioflupane-specific uptake ratios were calculated for caudate nucleus and putamen using the occipital cortex as reference region. We found no differences between the LRRK2-PD group and IPD in all items studied. In particular, putamen and caudate uptake values as well as side asymmetry indexes and putamen/caudate ratios all revealed comparable between-group values. We conclude that in these patients carrying the LRRK2 Gly2019Ser mutation, the neurodegenerative process results in a pattern of nigrostriatal dopaminergic dysfunction similar to that observed in IPD. |
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Keywords: | [123I]ioflupane SPECT LRRK2 PARK8 Gly2019Ser mutation |
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