Octodon degus: A Model for the Cognitive Impairment Associated with Alzheimer's Disease |
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| Authors: | Ernesto Tarragon Dolores Lopez Cristina Estrada Gonzalez‐Cuello Ana Esther Schenker Fabien Pifferi Regis Bordet Jill C Richardson Maria Trinidad Herrero |
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| Institution: | 1. Clinical & Experimental Neuroscience (NiCE) and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), School of Health Sciences (Medicine), University Jaume I of Castellon, , Castellon de la Plana, Spain;2. School of Medicine, University of Murcia, , Murcia, Spain;3. Institut de Recherches Servier, , Croissy, France;4. UMR Centre National de la Recherche Scientifique/Museum National d'Histoire Naturelle, , Brunoy, France;5. Department of Medical Pharmacology, Faculty of Medicine, University Lille‐North of France, , Lille, France;6. GlaxoSmithKline, R&D China U.K. Group, , Stevenage, Herts, UK |
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| Abstract: | Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concerned with neurodegenerative diseases in which risk is associated with aging. Octodon degus spontaneously develops β‐amyloid deposits analogous to those observed in some cases of Alzheimer's disease (AD). Moreover, these deposits are thought to be the key feature for AD diagnosis, and one of the suggested causes of cell loss and cognitive deficit. This review aims to bring together information to support O. degus as a valuable model for the study of AD. |
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| Keywords: | Alzheimer disease Amyloid beta‐protein Memory Mild Cognitive Impairment
Octodon degus
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