Cardiovascular magnetic resonance left ventricular strain in end-stage renal disease patients after kidney transplantation |
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Authors: | Inna Y. Gong Bandar Al-Amro G. V. Ramesh Prasad Philip W. Connelly Rachel M. Wald Ron Wald Djeven P. Deva Howard Leong-Poi Michelle M. Nash Weiqiu Yuan Lakshman Gunaratnam S. Joseph Kim Charmaine E. Lok Kim A. Connelly Andrew T. Yan |
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Affiliation: | 1.University of Toronto,Toronto,Canada;2.Department of Medical Imaging,St Michael’s Hospital,Toronto,Canada;3.Keenan Research Centre,Li Ka Shing Knowledge Institute, St. Michael’s Hospital,Toronto,Canada;4.Terrence Donnelly Heart Centre,St. Michael’s Hospital,Toronto,Canada;5.Division of Nephrology,St Michael’s Hospital,Toronto,Canada;6.Division of Cardiology,Toronto General Hospital,Toronto,Canada;7.Division of Nephrology, Department of Medicine, London Health Sciences Centre, Schulich School of Medicine and Dentistry,Western University,London,Canada;8.Department of Medicine, Division of Nephrology,Toronto General Hospital, University Health Network,Toronto,Canada;9.Department of Medicine,University Health Network-Toronto General Hospital,Toronto,Canada;10.Division of Cardiology,St. Michael’s Hospital,Toronto,Canada |
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Abstract: | BackgroundCardiovascular disease is a significant cause of morbidity and mortality in patients with end-stage renal disease (ESRD) and kidney transplant (KT) patients. Compared with left ventricular (LV) ejection fraction (LVEF), LV strain has emerged as an important marker of LV function as it is less load dependent. We sought to evaluate changes in LV strain using cardiovascular magnetic resonance imaging (CMR) in ESRD patients who received KT, to determine whether KT may improve LV function.MethodsWe conducted a prospective multi-centre longitudinal study of 79 ESRD patients (40 on dialysis, 39 underwent KT). CMR was performed at baseline and at 12?months after KT.ResultsAmong 79 participants (mean age 55 years; 30% women), KT patients had significant improvement in global circumferential strain (GCS) (p?=?0.007) and global radial strain (GRS) (p?=?0.003), but a decline in global longitudinal strain (GLS) over 12?months (p?=?0.026), while no significant change in any LV strain was observed in the ongoing dialysis group. For KT patients, the improvement in LV strain paralleled improvement in LVEF (57.4?±?6.4% at baseline, 60.6%?±?6.9% at 12?months; p?=?0.001). For entire cohort, over 12?months, change in LVEF was significantly correlated with change in GCS (Spearman’s r?=???0.42, p?0.001), GRS (Spearman’s r?=?0.64, p?0.001), and GLS (Spearman’s r?=???0.34, p?=?0.002). Improvements in GCS and GRS over 12?months were significantly correlated with reductions in LV end-diastolic volume index and LV end-systolic volume index (all p?0.05), but not with change in blood pressure (all p?>?0.10).ConclusionsCompared with continuation of dialysis, KT was associated with significant improvements in LV strain metrics of GCS and GRS after 12?months, which did not correlate with blood pressure change. This supports the notion that KT has favorable effects on LV function beyond volume and blood pessure control. Larger studies with longer follow-up are needed to confirm these findings. |
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