Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition,plaque load,and glial activation in the J20 Alzheimer mouse model |
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| Authors: | Doortje W Dekens Petrus J W Naudé Jan N Keijser Ate S Boerema Peter P De Deyn Ulrich L M Eisel |
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| Institution: | 1.Department of Neurology and Alzheimer Research Center,University Medical Center Groningen, University of Groningen,Groningen,The Netherlands;2.Department of Molecular Neurobiology,Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen,Groningen,The Netherlands;3.Department of Nuclear Medicine and Molecular Imaging,University Medical Center Groningen, University of Groningen,Groningen,The Netherlands;4.Laboratory of Neurochemistry and Behavior, Biobank, Institute Born-Bunge, University of Antwerp,Antwerp,Belgium;5.University Center of Psychiatry & Interdisciplinary Center of Psychopathology of Emotion Regulation, University Medical Center Groningen, University of Groningen,Groningen,The Netherlands |
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| Abstract: | BackgroundLipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple neurodegenerative conditions. Interestingly, both neuroprotective and neurodegenerative effects have been described for Lcn2. Increased Lcn2 levels were found in human post-mortem Alzheimer (AD) brain tissue, and in vitro studies indicated that Lcn2 aggravates amyloid-β-induced toxicity. However, the role of Lcn2 has not been studied in an in vivo AD model. Therefore, in the current study, the effects of Lcn2 were studied in the J20 mouse model of AD.MethodsJ20 mice and Lcn2-deficient J20 (J20xLcn2 KO) mice were compared at the behavioral and neuropathological level.ResultsJ20xLcn2 KO and J20 mice presented equally strong AD-like behavioral changes, cognitive impairment, plaque load, and glial activation. Interestingly, hippocampal iron accumulation was significantly decreased in J20xLcn2 KO mice as compared to J20 mice.ConclusionsLcn2 contributes to AD-like brain iron dysregulation, and future research should further explore the importance of Lcn2 in AD. |
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