Reference ranges for rotational thromboelastometry in male Sprague Dawley rats期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Reference ranges for rotational thromboelastometry in male Sprague Dawley rats

Authors:	Mariana Vigiola Cruz Jenna N Luker Bonnie C Carney Kathleen E Brummel-Ziedins Maria-Cristina Bravo Thomas Orfeo Jason H Chen Lauren T Moffatt Jeffrey W Shupp

Institution:	1.Firefighters’ Burn and Surgical Research Laboratory,MedStar Health Research Institute,Washington,USA;2.The Burn Center,MedStar Washington Hospital Center,Washington,USA;3.Department of Surgery,MedStar Georgetown University Hospital,Washington,USA;4.Department of Biochemistry,University of Vermont College of Medicine,Colchester,USA;5.Department of Surgery,MedStar Washington Hospital Center,Washington,USA

Abstract:	Background A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system. Methods Reference values for coagulation parameters from forty-three animals were calculated using data obtained from the ROTEM® delta hemostasis analyzer with the EXTEM test. Results The following ranges, presented as the 2.5–97.5 percentiles, were established: CT 18–77], CFT 20–80], α 73–86], MCF 53–70], and ML 1–22], along with others. Conclusions These reference ranges can be used in future studies in rats to identify clinically significant coagulopathies.

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