A New i,i + 3 Peptide Stapling System for α‐Helix Stabilization |
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| Authors: | So Youn Shim Young‐Woo Kim Gregory L. Verdine |
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| Affiliation: | 1. Departments of Chemistry and Chemical Biology, Stem Cell and Regenerative Biology, Harvard University, , Cambridge, MA, 02138 USA;2. Program in Cancer Chemical Biology, Dana‐Farber Cancer Institute, , Boston, MA, 02115 USA |
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| Abstract: | We have previously shown that the incorporation of an 8‐atom all‐hydrocarbon ‘staple’ at positions i and i + 3 of a synthetic peptide results in substantial stabilization of the α‐helical conformation. As part of our ongoing effort to explore the scope and utility of all‐hydrocarbon stapling systems, we have investigated and report herein the properties of a new i, i + 3 stapling system that employs a 6‐carbon cross‐link. |
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| Keywords: | stapled peptides α ‐helix ring‐closing metathesis |
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