烧伤创面脓毒症的防治对策

烧创伤破坏皮肤连续性及完整性,影响机体免疫反应,甚至诱导免疫抑制。感染是重度烧伤患者常见、严重甚至致死的并发症。创面脓毒症是创面严重感染导致的全身性炎症反应,是烧伤患者主要死因之一。创面脓毒症的治疗重在预防。对创面及时、有效的处置是防治创面脓毒症的基础及关键。在传统抗感染治疗策略基础上,探索抗感染治疗的新方向、新制剂对于缓解抗菌药物耐药、改善创面脓毒症患者预后具有重要意义。针对创面脓毒症病原菌的免疫治疗亦具有广阔的临床应用前景。

Prevention and management of burn wound sepsis

Burn injury disrupts the integrity and continuity of skin, damages body immune response and even results in immune paralysis.Infections are common, severe and even lethal complications of burn patients.Burn wound sepsis is the state of systemic inflammatory response, usually accompanied by multi-organ dysfunction, which has become one of the major causes for mortality.Prevention is of the highest importance to the treatment of burn wound sepsis.Prompt and proper management of local burn wound is a key and fundamental step.Based on conventional antibiotic therapies, new agents, novel strategies and immune therapy deserve more attention and should be further investigated.Immune therapy aimed at the pathogenic bacteria has broad prospects.