| 慢性心力衰竭患者血浆谷胱甘肽抗氧化系统的变化及意义 |
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| 引用本文： | 李增玉. 慢性心力衰竭患者血浆谷胱甘肽抗氧化系统的变化及意义[J]. 中国现代医药杂志, 2008, 10(9) |
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| 作者姓名： | 李增玉 |
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| 作者单位： | 山西省宁武县人民医院,036700 |
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| 摘 要： | 目的 研究慢性心力衰竭(CHF)患者血浆谷胱甘肽抗氧化系统的改变及其临床意义.方法 选择2006年1月至2006年9月收住我院心内科慢性心力衰竭的住院患者53例为观察组,门诊体检健康者25例为对照组.按NYHA心功能分级将CHF组分为心功能Ⅱ级组(n=11例),心功能Ⅲ级组(n=15例),心功能Ⅳ级组(n=27例).所有患者均于入院后第2天采空腹静脉血,应用酶循环法测定血浆还原型谷胱甘肽(GSH)、氧化型谷胱甘肽(GSSG)浓度,根据Nemst公式计算氧化还原电位(EhGSH/GSSG).结果 ①CHF组血浆GSH浓度较对照组明显下降(5.23±0.77)umol/L vs(6.52 1.02)umol/L,P<0.05);CHF组血浆GSSG浓度高于对照组(1.51±0.4)umol/L vs(1.16±0.53)umol/L,P<0.05,CHF组EhCSJ/GSSG值较对照组升高(-122.92±4.37)mV vs(-133.67±3.49)mV.P<0.05.②CHF各亚组患者血浆GSH浓度、GSSG浓度、EhCSJ/GSSG值在心功能Ⅱ级组与Ⅲ、Ⅳ级组之间有显著性差异(P<0.05),Ⅲ、Ⅳ级组之间无差异.结论 心衰时存在氧化应激,机体的抗氧化作用减弱;血浆GSH浓度、GSSG浓度及EhCSJ/GSSG值均与心功能存在相关性,可作为反映心功能的指标.
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| 关 键 词： | 慢性心力衰竭 谷胱甘肽抗氧化系统 GSH GSSG EhGSH/GSSG |
The changes and clinical significance of glutathione redox-state in chronic heart failure patients |
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| Li Zengyu. The changes and clinical significance of glutathione redox-state in chronic heart failure patients[J]. Modern Medicine Journal of China, 2008, 10(9) |
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| Authors: | Li Zengyu |
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| Affiliation: | Li Zengyu. People's Hospital of Ningwu County of Shanxi Province,Ningwu 036700 |
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| Abstract: | Objective To research the change and clinical significance of glutathione redox-state in chronic heart failure(CHF) patients. Methords Total of 53 hospitalized patients as observed group and 25 healthy people as control group were selected. According to NYHA heart function grade, the CHF group were classfied into 3 subgroups II, III, IV grade. Samples of peripheral venous blood with heparin as anticoagulant were obtained from aforesaid patients on empty stomach in morning, then the sample were centrifuged a... |
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| Keywords: | GSH GSSG EhGSJ/GSSG |
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