辛伐他汀对急性脑梗死患者血脂、高敏C反应蛋白、脂联素及血清抵抗素的影响

目的观察辛伐他汀对急性脑梗死患者血脂、高敏C反应蛋白（hs-CRP）、脂联素（APN）及血清抵抗素的影响。方法将入选的90例急性脑梗死患者随机分为治疗组45例和对照组45例,对照组用常规方法治疗,不服用他汀类药物。治疗组在对照组常规治疗的基础上给予辛伐他汀20 mg/次每晚临睡前口服。2组均连续治疗14 d。观察2组疗效及血脂、血清hs-CRP、APN和抵抗素水平变化。结果治疗组的总有效率（87%）明显高于对照组（64%）,治疗后2组三酰甘油、低密度脂蛋白胆固醇、hs-CRP和抵抗素水平均较治疗前明显下降,而治疗组的hs-CRP和抵抗素水平较对照组下降更为明显。2组高密度脂蛋白胆固醇和APN水平均较治疗前明显升高,治疗组较对照组升高更明显。结论辛伐他汀能有效调整血脂、血清hs-CRP、APN和血清抵抗素水平,减轻血管炎性反应,且安全性好。

Effect of simvastatin on blood fat,high sensitivity C reactive protein,adiponectin and serum resistin in patients with acute cerebral infarction

Objective It is to observe the effect of simvastatin on blood fat,high sensitivity C reactive protein（hs-CRP）,adiponectin（APN） and serum resistin in patients with acute cerebral infarction.Methods 90 patients with acute cerebral infarction were randomly divided into treatment group（45 patients）and control group（45 patients）.The control group received routine treatment,without taking statins,and the treatment group were added with simvastatin calcium in every evening before sleep（20 mg/time）on the basis of conventional treatment in the control group.Both groups were treated continuously for 14 days.The efficacy,levels of blood fat,hs-CRP,APN and serum resistin were observed in both groups before and after treatment.Results After treatment,total effective rate was 87% in treatment group,which was significantly higher than 64% in control group.The levels of triglyceride（TG）,low density lipoprotein cholesterol（LDL-C）,hs-CRP and serum resistin in both groups were significantly lower than that before treatment（P0.01） and the levels of treatment group were more obvious than those of control group（P0.05 or 0.01）.While,the levels of high density lipoprotein cholesterol（HDL-C） and APN increased in both groups compared with those before treatment（P0.01）,the levels of treatment were obvious than those of control group（P0.05 or 0.01）.Conclusion Simvastatin can effectively adjust the levels of blood fat,hs-CRP,adiponectin and serum resistin,alleviate blood vessel inflammation,its effect is obvious and security is good.