1.Unité de génétique humaine et moléculaire,CHUQ-H?pital St-Fran?ois d'Assise,Québec,Canada;2.Department of Pediatrics,Laval University,Québec,Canada
Abstract:
Background
Fanconi anemia (FA) is a complex recessive genetic disease characterized by progressive bone marrow failure (BM) and a predisposition to cancer. We have previously shown using the Fancc mouse model that the progressive BM failure results from a hematopoietic stem cell defect suggesting that function of the FA genes may reside in primitive hematopoietic stem cells.