| 尼莫地平在防治蛛网膜下腔出血后脑血管痉挛的Meta分析 |
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| 引用本文： | 鲁虎臣,赵旭东,周怡婷,史继新. 尼莫地平在防治蛛网膜下腔出血后脑血管痉挛的Meta分析[J]. 蚌埠医学院学报, 2010, 35(11): 1106-1109. DOI: 10.3969/j.issn.1000-2200.2010.11.010 |
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| 作者姓名： | 鲁虎臣 赵旭东 周怡婷 史继新 |
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| 作者单位： | 1. 南京大学医学院临床学院南京军区总医院神经外科, 江苏南京 210002;2. 江苏省无锡市第三人民医院影像科, 214041 |
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| 摘 要： | 目的:系统评价尼莫地平注射液治疗蛛网膜下腔出血(subarachnoid hemorrhage,SAH)后脑血管痉挛(cerebral vasospasm,CVS)的临床疗效及安全性。方法:检索1994~2007年国内发表的尼莫地平注射液治疗SAH后CVS临床对照试验的相关文献,利用M eta分析方法,采用Review Manager 4.2软件对符合条件的文献进行荟萃分析。结果:对符合标准的16项临床研究结果进行同质性检验表明各试验具有同质性(P>0.05)。Meta分析结果表明尼莫地平注射液能够减少住院期间SAH后CVS的发生率,病死率明显低于对照组(P<0.000001);不会引起再出血发生率的增加(P=0.17)。结论:现有的临床研究证据显示尼莫地平能够有效防治SAH后CVS,降低病死率且未增加再出血的危险。
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| 关 键 词： | 蛛网膜下腔出血 尼莫地平 脑血管痉挛 META分析法 |
| 收稿时间： | 2009-05-22 |
Nimodipine for cerebral vasospasm after subarachnoid hemorrhage:a Meta analysis |
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| LU Hu-chen,ZHAO Xu-dong,ZHOU Yi-ting,SHI Ji-xin. Nimodipine for cerebral vasospasm after subarachnoid hemorrhage:a Meta analysis[J]. Journal of Bengbu Medical College, 2010, 35(11): 1106-1109. DOI: 10.3969/j.issn.1000-2200.2010.11.010 |
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| Authors: | LU Hu-chen ZHAO Xu-dong ZHOU Yi-ting SHI Ji-xin |
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| Affiliation: | 1. Department of Neurosurgery, Nanjing General Hospital of Nanjing Military Command, School of Medicine, Nanjing University, Nanjing Jiangsu 210002;2. Department of Radiology, Wuxi Third People′s Hospital, Wuxi Jiangsu 214041, China |
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| Abstract: | Objective:To evaluate systematically the efficacy and safety of nimodipine injection in the treatment of patients suffering from cerebral vasospasm after subarachnoid hemorrhage.Methods:By overall collecting the related literature of controlled clinical trials about nimodipine injection for the treatment of cerebral vasospasm after subarachnoid hemorrhage from 1994 to 2007,Meta analysis was conducted by means of Review with Manager 4.2 software.Results:The homogenecity test of 16 selected clinical research ... |
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| Keywords: | subarachnoid hemorrhage nimodipine cerebral vasospasm Meta analysis |
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