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| 5%咪喹莫特乳膏治疗尖锐湿疣的临床研究 | |
| 引用本文： | 陶苏江,顾军,赵广,李明. 5%咪喹莫特乳膏治疗尖锐湿疣的临床研究[J]. 中国皮肤性病学杂志, 2006, 20(3): 147-148,160 |
| 作者姓名： | 陶苏江 顾军 赵广 李明 |
| 作者单位： | 1. 上海长海医院皮肤科,上海,200433 2. 北京空军总医院皮肤科,北京,100036 3. 上海复旦大学中山医院,上海,200032 |
| 摘 要： | 目的探讨5%咪喹莫特乳膏治疗尖锐湿疣的有效性和安全性。方法采用多中心、随机、双盲、安慰剂平行对照法对236例尖锐湿疣患者进行了8周的临床研究。结果有116例治疗组患者和120例对照组患者完成临床观察并纳入统计分析。两组治疗后2周、6周及治疗后8周在疗效评价方面有显著差异(P<0.05),不良反应主要是轻至中度的红斑、水肿、糜烂、刺痛及瘙痒。结论5%咪喹莫特乳膏是一种治疗外生殖器疣有效而安全的新药。 |
| 关 键 词： | 咪喹莫特乳膏 尖锐湿疣 有效性 安全性 |
| 文章编号： | 1001-7089（2006）03-0147-02 |
| 收稿时间： | 2005-06-27 |
| 修稿时间： | 2005-06-272005-11-20 |
Evaluation of Topical 5% Imiquimod Cream on the Treatment of Condylomata Acuminata |
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| TAO Su-jiang, GU Jun, ZHAO Guang, et al. Evaluation of Topical 5% Imiquimod Cream on the Treatment of Condylomata Acuminata[J]. The Chinese Journal of Dermatovenereology, 2006, 20(3): 147-148,160 | |
| Authors: | TAO Su-jiang GU Jun ZHAO Guang et al |
| Affiliation: | Department of Dermatology, Changhai Hospital,Shanghai 200433, China |
| Abstract: | Objective To evaluate the efficacy and safety of topical 5% imiquimod cream in the treatment of condylomata acuminate.Methods A double-blind,controlled study in which patients with condylomata acuminate were randomized to 8 weeks of treatment with 5% imiquimod cream or the cream base.Results 116 patients were randomized to topical 5% imiquimod cream and 120 patients to placebo.Significant difference of efficacy between the two groups were observed after weeks of 2,6 and 8(P<0.05).The most common adverse effects were slight or moderate erythema,edema,erosion and itching.Conclusion Topical 5% imiquimod cream is effective and safe therapy for extra-genital warts. |
| Keywords: | Imiquimod cream Condylomata acuminate Efficacy Safety |
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