Clinical characteristics of severe peripheral neuropathy induced by docetaxel (Taxotere) |
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Authors: | P. H. E. Hilkens J. Verweij Ch. J. Vecht G. Stoter M. J. van den Bent |
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Affiliation: | (1) Department of Neuro-Oncology, Rotterdam Cancer Institute and University Hospital, Rotterdam, the Netherlands;(2) Medical Oncology, Rotterdam Cancer Institute and University Hospital, Rotterdam, the Netherlands |
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Abstract: | Background: Docetaxel, a semi-synthetic taxane may cause a usuallymild sensory neuropathy. We describe the clinical characteristics of fivepatients who developed a more severe neuropathy following treatment withdocetaxel.Patients and methods: All patients were treated in phase II studieswith 100 mg/m2 docetaxel in three weekly cycles, withoutsteroid administration.Results: The clinical picture in these patients was dominated by asensory neuropathy, but in one case severe weakness was present. Anotherpatient developed Lhermitte's sign. Signs and symptoms are usually reversibleafter discontinuation of docetaxel administration, but in three patientssymptoms worsened for some time after the end of treatment before improvementoccurred.Conclusion: Severe docetaxel neuropathy may especially occurfollowing treatment with cumulative dosage over 600 mg/m2; inpatients treated with this dosage a moderate or severe neuropathy may not berare. |
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Keywords: | docetaxel Lhermitte's sign neuropathy taxotere |
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