| ACE基因多态性与ADPKD的关系 |
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| 引用本文： | 毕敏,薛继强,张淼.ACE基因多态性与ADPKD的关系[J].哈尔滨医科大学学报,2005,39(1):41-43. |
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| 作者姓名： | 毕敏 薛继强 张淼 |
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| 作者单位： | 哈尔滨医科大学第二临床医学院,肾内科,黑龙江,哈尔滨,150086;哈尔滨医科大学第二临床医学院,肾内科,黑龙江,哈尔滨,150086;哈尔滨医科大学第二临床医学院,肾内科,黑龙江,哈尔滨,150086 |
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| 基金项目： | 黑龙江省自然科学基金资助项目 (D0 3 0 3 ) |
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| 摘 要： | 目的 探讨血管紧张素-Ⅰ转换酶基因(ACE基因)插入／缺失(I/D)多态性与常染色体显性遗传性多囊肾病(ADPKD)之间的关系。方法 应用聚合酶链式反应(PCR)方法对62例ADPKD患者和96例健康对照者ACE基因多态性进行了分析。结果 ADPKD患者与健康对照组之间ACE基因型频率差异不明显；ADPKD肾功能不全组与健康对照组之间DD型及D等位基因频率差异有显著性。结论 ACE基因多态性与中国人ADPKD的发病无明显相关性。DD型基因是ADPKD发生肾功能不全的易感因素。
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| 关 键 词： | 血管紧张素转换酶 基因多态性 多囊肾 |
| 文章编号： | 1000-1905(2005)01-0041-03 |
| 修稿时间： | 2004年10月15 |
Relationship between angiotensin converting enzyme gene polymorphism and autosomal dominant polycystic kidney disease |
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| BI Min,XUE Ji-qiang,ZHANG Miao.Relationship between angiotensin converting enzyme gene polymorphism and autosomal dominant polycystic kidney disease[J].Journal of Harbin Medical University,2005,39(1):41-43. |
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| Authors: | BI Min XUE Ji-qiang ZHANG Miao |
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| Abstract: | Objective To investigate the relationship between insertion/deletion(I/D) polymorphism of angiotension converting enzyme(ACE) gene and autosomal dominant polycystic kidney disease(ADPKD).Methods Polymerase chain reaction(PCR) was used to determine the ACE gene polymorphism in 62 patients with ADPKD and 96 healthy subjects as controls.Results The genotype distribution was not significantly different between ADPKD and normal controls.The DD genotype frequency was significantly higher in ADPKD patients of chronic renal failure.Conclusion The ACE gene I/D polymorphism may not contribute to the happen of ADPKD;The DD genotype of ACE may be a risk marker for the ADPKD to the renal failure stage. |
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| Keywords: | angiotension converting enzyme gene polymorphism polycystic kidney |
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