| PI3K／Akt／mTOR信号转导通路与卵巢癌研究进展 |
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| 引用本文： | 朱颖军（综述）,高企贤（审校）. PI3K／Akt／mTOR信号转导通路与卵巢癌研究进展[J]. 国外医学:妇产科学分册, 2009, 0(2): 135-139 |
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| 作者姓名： | 朱颖军（综述） 高企贤（审校） |
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| 作者单位： | 天津市中心妇产科医院; |
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| 摘 要： | 磷脂酰肌醇3激酶，蛋白激酶B／哺乳动物雷帕霉素靶体蛋白（P13K／Akt／mTOR）信号转导通路通过PTEN基因功能的失常或者被其他信号激活后，抑制细胞凋亡，促进细胞周期运行，致细胞增殖，促进血管形成和恶性肿瘤的侵袭和转移，在卵巢癌的发生和发展中发挥重要作用，且与卵巢癌化疗耐药密切相关。因此该通路中的受体及激酶可能成为卵巢癌抗癌药物的潜在靶点，随着对该通路研究的逐渐深入以及抑制剂的发现和发明，针对该信号转导通路开发新的肿瘤治疗药物，靶向基因治疗，以及寻找降低化疗耐药的方法．无疑对卵巢癌治疗具有重要意义。
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| 关 键 词： | 磷脂酰肌醇3激酶 丝氨酸/苏氨酸蛋白激酶 哺乳动物雷帕霉素靶体蛋白 信号通路 卵巢癌 |
Research Progress of PI3K/Akt/mTOR Signal Pathway and Ovarian Carcinoma |
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| ZHU Ying-jun,GAO Qi-xian.Tianjin Central Maternity Hospital,Tianjin ,China. Research Progress of PI3K/Akt/mTOR Signal Pathway and Ovarian Carcinoma[J]. Foreign Medical Sciences(Obstet Gynecol Fascicle), 2009, 0(2): 135-139 |
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| Authors: | ZHU Ying-jun GAO Qi-xian.Tianjin Central Maternity Hospital Tianjin China |
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| Affiliation: | ZHU Ying-jun,GAO Qi-xian.Tianjin Central Maternity Hospital,Tianjin 300052,China |
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| Abstract: | PI3K/Akt/mTOR signaling pathway play a central role in the promotion of malignant cell proliferation and invasion, cell cycle and angiogenesis, inhibition of apoptosis while PTEN gene is abnormal or activated by other signals in malignant cells.It plays a significant effect on genesis and development of ovarian cancer, and is closely related to the chemotherapy resistance.These receptors and kinases can be the candidate genes for gene therapy or drug targets of ovarian cancer.With the research on the PI3K/A... |
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| Keywords: | Phosphatidylinositol 3-kinase Serine/threonine kinase Mammalian target of rapamycin Signaling pathway Ovarian cancer |
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