去势后大鼠腹叶前列腺微循环的改变

目的:探讨去势后大鼠腹叶前列腺微循环的改变,及微循环的改变对前列腺细胞凋亡的作用。　方法: Sprague Dawley雄性大鼠36只,随机分为6组,一组作正常对照,其余5组分别于去势后12h、24h、72h、7d和14d 采用D95生理信号采集系统行活体微循环测量,然后再行墨汁灌注示踪微血管床变化。　结果:去势后大鼠腹叶前 列腺微循环发生显著改变,微血管密度和直径下降,流速减慢,以远端腺管最为显著。　结论:大鼠去势后前列腺微 循环的改变参与了前列腺细胞凋亡的机制,可能是前列腺“凋亡漂移现象”的机制。

Microcirculation Changes in the Ventral Prostates of Rats after Castration

Objective: To study the microcirculation changes in the ventral prostates of rats after castration and the role of microcirculation during the apoptosis of prostatic cells. Methods: Thirty-six male adult rats were randomized to 6 groups: one was taken as the control, while the other 5 underwent measurement of the microcirculation in vivo by a D95 physiological signal acquisition system 12 h, 24 h, 72 h, 7 d and 14 d respectively after castration, and then were perfused with Chinese ink to trace the microvessels of the prostates. Results: The microcirculation of the rats' prostates changed dramatically following castration. The diameter and density of the microvessels, especially in the distant and mediate ducts of the prostates, decreased dramatically, and so did the bloodflow velocity. Conclusion: The microcirculation plays a role during the process of apoptosis of prostatic cells, and might be the mechanism of "apoptosis shift".