| 环孢素A在重症肌无力患者中的群体药动学模型的建立 |
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| 引用本文： | 马萍,吴小枫,童卫杭,罗静,陈慧,张晓菲,高文静,孙健姿. 环孢素A在重症肌无力患者中的群体药动学模型的建立[J]. 中国医院药学杂志, 2011, 0(5) |
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| 作者姓名： | 马萍 吴小枫 童卫杭 罗静 陈慧 张晓菲 高文静 孙健姿 |
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| 作者单位： | 中国人民解放军第二炮兵总医院;厦门大学医学院药学系; |
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| 摘 要： | 目的:建立环孢素A在重症肌无力患者中的群体药动学模型,了解影响环孢素A代谢的显著影响因素。方法:回顾性搜集82例服用环孢素A的重症肌无力患者的91个血药浓度及其相关资料,利用SPSS软件和逐步回归法分两次建立群体药动学模型,运用内部验证法对模型进行验证。结果:最终所得模型为Ln(Cl/F)=-4.418+1.598Ln(HGB)+0.008W,表明患者的体质量(W)及血红蛋白(HGB)含量对环孢素A在重症肌无力患者体内的代谢影响较大,模型对血药浓度的预测值与实测值误差为15.96%。结论:用SPSS软件和逐步回归法建立的群体药动学型有一定的预测能力,可以用于指导临床给药,并且在样本量增大时,模型会逐渐完善,此法简单易行,值得推广。
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| 关 键 词： | 环孢素A 重症肌无力 群体药动学 |
Population pharmacokinetics of cyclosporine in patients with myasthenia gravis |
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| MA Ping,WU Xiao-feng,TONG Wei-hang,LUO Jing,CHEN Hui,ZHANG Xiao-hui,GAO Wen-jing,SUN Jian-zi. Population pharmacokinetics of cyclosporine in patients with myasthenia gravis[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(5) |
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| Authors: | MA Ping WU Xiao-feng TONG Wei-hang LUO Jing CHEN Hui ZHANG Xiao-hui GAO Wen-jing SUN Jian-zi |
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| Affiliation: | MA Ping1,WU Xiao-feng2,TONG Wei-hang1,LUO Jing1,CHEN Hui1,ZHANG Xiao-hui1,GAO Wen-jing1,SUN Jian-zi1(1.The PLA Second Artillery general hospital,Beijing 100088,China,2.Pharmacy department,Medical College,Xiamen University,Fujian Xiamen 361005,China) |
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| Abstract: | OBJECTIVE The aim of this study is to establish a population pharmacokinetic(PPK) model of cyclosporine in patients with myasthenia gravis.METHODS Sparse data of cyclosporine serum concentrations from 82 patients with myasthenia gravis in our hospital were collected and investigated by SPSS program.RESULTS The final model was: Ln(Cl/F)=-4.418+1.598Ln(HGB)+0.008W,showing that hemoglobin(HGB) and weight(W) had very significant effect on cyclosporine serum concentrations.CONCLUSION The PPK model of cyclosporin... |
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| Keywords: | cyclosporine A myasthenia gravis population pharmacokinetics |
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