| 羟基喜树碱缓释片制备质量评价及稳定性考察 |
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| 引用本文： | 胡婧,刘松青. 羟基喜树碱缓释片制备质量评价及稳定性考察[J]. 中国医院药学杂志, 2011, 0(5) |
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| 作者姓名： | 胡婧 刘松青 |
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| 作者单位： | 第三军医大学西南医院药学部; |
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| 摘 要： | 目的:对自制羟基喜树碱(HCPT)缓释片进行质量评价以及初步稳定性考察。方法:对以最优处方所制备的缓释片进行片质量差异、含量均匀性以及释放均一性测定和质量控制;缓释片分别于空气、高温、高湿、光照条件下放置,测定其稳定性。结果:自制HCPT缓释片的片质量差异限度符合规定,含量约在20%左右,释放均一性良好;经各种影响因素试验,仅高温对制剂的外观、含量、累积释放百分率等无显著性影响。结论:自制HCPT缓释片制剂应在30℃,25%相对湿度条件下避光保存。
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| 关 键 词： | 羟基喜树碱 缓释片 质量评价 稳定性 |
Determination of the quality and stability of the hydroxycamptothecin sustained-released tablets |
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| HU Jing,LIU Song-qing. Determination of the quality and stability of the hydroxycamptothecin sustained-released tablets[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(5) |
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| Authors: | HU Jing LIU Song-qing |
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| Affiliation: | HU Jing,LIU Song-qing (Department of Pharmacy,Southwest Hospital,Third Medical University,Chongqing 400038,China) |
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| Abstract: | OBJECTIVE To investigate the quality and stability of hydroxycamptothecin(HCPT) sustained-released tablets(SRT).METHODS Evaluating the SRT quality via determination of weight variation,content uniformity and release homogeneity;after exposure to air,high temperature,high humidity or light,determination of the SRT stability.RESULTS The weight variation of prepared SRT consistent with regulation,content was 20%,release homogeneity was good;the influencing factor test showed the SRT need to preserve under dryi... |
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| Keywords: | hydroxycamptothecin sustained-released tablet quality determination stability |
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