| 单相抑郁症中5-HT2A受体基因及MAOA型
基因的相互影响 |
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| 引用本文： | 江开达,江三多,王红霞,杨晓敏,王慧芳,林嗣萃,钱伊萍.单相抑郁症中5-HT2A受体基因及MAOA型
基因的相互影响[J].中国神经精神疾病杂志,1999(2):0. |
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| 作者姓名： | 江开达 江三多 王红霞 杨晓敏 王慧芳 林嗣萃 钱伊萍 |
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| 作者单位： | 上海医科大学精神医学教研室，上海精神卫生中心，湖北沙市精神病院 |
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| 摘 要： | 目的探讨单相抑郁症病因中５－ＨＴ２Ａ受体基因与ＭＡＯＡ型基因的相互影响。方法在７２例单相抑郁症患者和８１例正常健康人中，采用ＰＣＲ－ＲＦＬＰ和Ａｍｐ－ＦＬＰ技术检测５－ＨＴ２Ａ和ＭＡＯＡ型的等位基因和基因型分布。结果单相抑郁症与５－ＨＴ２Ａ基因间无遗传关联，但是具５－ＨＴ２Ａ的Ａ２／Ａ２基因型患者与ＭＡＯＡ型的１１４ｂｐ等位基因呈强烈关联（ＲＲ＝６．２５，Ｐ＜００５）。结论５－ＨＴ２Ａ受体基因和ＭＡＯＡ型基因在单相抑郁症发生中可能起有一定相互作用。
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| 关 键 词： | 单相抑郁症 5－HT2A受体基因 MAOA型基因 关联 |
An interaction between 5-HT 2A receptor gene and MAOA gene in unipolar depressive
patients. |
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| Jiang Kaida,Jiang Sanduo,Wang Hongxia,Yang Xiaoming,Wang Huifang,Lin
Shicui,Qian Yiping.An interaction between 5-HT 2A receptor gene and MAOA gene in unipolar depressive
patients.[J].Chinese Journal of Nervous and Mental Diseases,1999(2):0. |
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| Authors: | Jiang Kaida Jiang Sanduo Wang Hongxia Yang Xiaoming Wang Huifang Lin
Shicui Qian Yiping |
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| Institution: | Jiang Kaida,Jiang Sanduo,Wang Hongxia,Yang Xiaoming,Wang Huifang,Lin
Shicui,Qian Yiping.Shanghai Medical University,600Wangping Road,Shanghai.200032.
Tel:021-64387250 |
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| Abstract: | Objective To investigate the interaction between 5-HT 2A
receptor gene and MAOA gene in unipolar depressive patients. Methods The alleles and
genotypes of 5-HT 2A receptor gene and MAOA gene were examined with PCR-RFLP and
Amp-FLP techniques in 72 unipolar depressive patients and 81 healthy controls. Results There
was no correlation between unipolar depression and 5-HT 2A receptor gene,but the 114bp
allele of MAOA gene had a significant correlation with the unipolar depressive patients with
A2/A2 genotype of 5-HT 2A receptor gene ( RR=6.25,P <0.05). Conclusions An interaction
between 5-HT 2A receptor gene and MAOA gene may exist in the etiology of unipolar
depression. |
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| Keywords: | Unipolar depression 5-HT2A receptor gene MAOA gene Association |
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