成人重组酵母乙肝疫苗两种不同免疫程序接种效果观察

目的探讨成人乙肝疫苗两种不同免疫程序接种效果。方法对381名16～49岁年龄组HBsAg、抗-HBs、抗-HBc指标均为阴性者,采用0、1、3个月和0、1、6个月免疫程序接种10μg重组酵母乙肝疫苗,进行免疫效果观察。阳转率的比较采用χ2检验,抗-HBs GMT比较采用t检验,趋势检验采用相关分析,P〈0.05差异有统计学意义。结果应用国产10μg重组酵母乙肝疫苗,采取0、1、3个月和0、1、6个月免疫程序后1个月抗-HBs阳性率分别为88.95%和90.05%,差异无统计学意义（χ2=0.124,P〉0.05）;几何平均滴度（GMT）分别为94.95IU/L和145.12IU/L,差异有统计学意义（t=-2.007,P=0.045）;随着年龄增加,其免后抗–HBsGMT呈下降趋势（r=-0.117,P=0.023）。结论采取0、1、3个月和0、1、6个月免疫程序接种10μg重组酵母乙肝疫苗均可获得良好的抗体阳转率,后者产生的抗体滴度水平更高;且成人接种免疫年龄越小效果越好。

Effects of two immunization schedules of recombinant yeast-derived hepatitis B vaccine for adults

Objective To evaluate the effects of recombinant yeast-derived hepatitis B vaccine for adults vaccinated based on two immunization schedules.Methods A total of 381 adults aged 16-49 years with negative HBsAg,anti-HBs,and anti-HBc were randomly enrolled in the study.190 were inoculated 10 μg recombinant yeast-derived hepatitis B vaccine at months of 0,1 and 3,while others were vaccinated at months of 0,1 and 6.Anti-HBs level was measured one month after the final dose.Chi square test and t test were used to analyze the data.Results The positive rates of anti-HBs were 88.95% and 90.05% respectively,showing no significant difference between the two immunization schedules（χ2=0.124,P0.05）.However,the difference of geometric mean titer（GMT）was statistically significant（94.95mIU/ml vs 145.12 IU/L,t=-2.00,P0.05）.The GMT of anti-HBs showed a down-ward trend with age（r=-0.117,P=0.023）.Conclusions The anti-HBs seroconversion rates are both high among adults inoculated with recombinant yeast-derived hepatitis B vaccine with two schedules,especially among those immunized at months 0,1 and 6.The younger the adult is,the better the effect will be.