肝硬化鼠肝移植后早期全身和内脏血流动力学的变化

目的 观察正常鼠肝移植及及肝硬化鼠肝移植术早期全身和内脏血流动力学的变化。方法 实验动物随机分为正常鼠（NL，10只）、肝硬化鼠（IHPH，10只）、正常鼠肝移植（NL－OLT，9只）、肝硬化鼠肝移植（IHPH－OLT，16只）组。分别采用放射性微球法行血流动力学研究。结果 NLOLT鼠绝大多数血流动力学参数与NL鼠比较差异无显著意义。IHPH及IHPH－OLT 3d,7d组心输量和内脏血流量和内脏血流量增加，平均动脉压、周围血管总阻力和内脏血管阻力降低。内脏血流动力学紊乱较全身明显。结论 肝硬化鼠肝移植后的血流动力学紊乱可能与移植前已存在的病理生理因素有关。

Early alterations of systemic and splanchnic hemodynamics after orthotopic liver transplantation in cirrhotic rats

Objective　The purpose of this study was to investigate early alterations of systemic and splanchnic hemodynamics after orthotopic liver transplantation (OLT) in normal and cirrhotic rats.Methods Male SD rats were divided into 4 groups: normal controls (NL,n=10),intrahepatic portal hypertension (IHPH,n=10) induced by CCl4,normal rats with OLT (NL-OLT,n=9) and IHPH rats with OLT (IHPH-OLT,n=16).Radioactive microsphere method was used for hemodynamic study.Results　Increased cardiac output and splanchnic blood flow,decreased mean arterial blood pressure,total peripheral vascular resistance and splanchnic vascular resistance were found in IHPH,IHPH-OLT at day 3,and IHPH-OLT at day 7 in cirrhotic rats.The magnitude of hyperhemodynamic alterations was in the order of IHPH>IHPH-OLT (day 3) >IHPH-OLT (day 7) rats.Moreover,the derangement of splanchnic hyperhemodynamics was more significant than that of systemic hyperhemodynamics.Conclusions　The results demonstrated that systemic and splanchnic hyperkinetic abnormalities seen in early liver transplantation may come from the pretransplant pathophysiologic status in cirrhotic rats.