| 小窝蛋白-1与肺纤维化关系的研究进展 |
| |
| 引用本文： | 丁辉,周凤秋,蔡后荣. 小窝蛋白-1与肺纤维化关系的研究进展[J]. 国际呼吸杂志, 2010, 30(6). DOI: 10.3760/cma.j.issn.1673-436X.2010.06.012 |
| |
| 作者姓名： | 丁辉 周凤秋 蔡后荣 |
| |
| 作者单位： | 南京医科大学附属鼓楼临床医学院呼吸内科,210008;南京医科大学附属鼓楼临床医学院呼吸内科,210008;南京医科大学附属鼓楼临床医学院呼吸内科,210008 |
| |
| 基金项目： | 南京市医学重点科技发展项目 |
| |
| 摘 要： | 小窝蛋白-1(Caveolin-1)是小窝标志性的蛋白,主要通过脚手架结构区域,参与负性调控多条信号通路,干预多种疾病进程.目前研究证实:特发性肺纤维化的肺组织中的Caveolin-1表达明显减低,而提高Caveolin-1水平抑制转化生长因子β_1/Smad、JNK、MEK/ERK、wnt/β-Catenin/Lef-1等信号转导通路因子的激活,可减少细胞外基质的合成和上皮细胞的异常修复,阻断肺纤维化进程.深入研究Caveolin-1参与肺纤维化的分子机制,有望为特发性肺纤维化提供新的分子治疗靶点.
|
| 关 键 词： | 小窝蛋白-1 特发性肺纤维化 转化生长因子β_1 信号通路 |
Research progress of relationship between caveolin-1 and pulmonary fibrosis |
| |
| DING Hui,ZHOU Feng-qiu,CAI Hou-rong. Research progress of relationship between caveolin-1 and pulmonary fibrosis[J]. International Journal of Respiration, 2010, 30(6). DOI: 10.3760/cma.j.issn.1673-436X.2010.06.012 |
| |
| Authors: | DING Hui ZHOU Feng-qiu CAI Hou-rong |
| |
| Abstract: | As the character protein of caveolae, caveolin-1 negatively regulates many signaling molecules,and interferes the process of diseases by the caveolin scaffolding domain. It is reported that eaveolin-1 expression obviously decreases in lung tissues of idiopathic pulmonary fibrosis. Over-expression of caveolin-1 could decrease synthesis of extracellular matrix and abnormal reparation of epithelial cells, block the process of pulmonary fibrosis by inhibiting the molecular activation of transforming growth factor-β_1/Smad,JNK, MEK/ERK, Wnt/β-Catenin/Lef-1 signal pathways. It is hoped to provide novel molecular therapeutic targets for idiopathic pulmonary fibrosis that further study of molecular mechanism of caveolin-1 in pulmonary fibrosis. |
| |
| Keywords: | Caveolin-1 Idiopathic pulmonary fibrosis Transforming growth factor-β_1 Signalpathway |
| 本文献已被 万方数据 等数据库收录！ |
|
