| 小檗碱治疗非酒精性脂肪肝并血脂紊乱的临床观察 |
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| 引用本文： | 白梅,任孟军,刘忠和.小檗碱治疗非酒精性脂肪肝并血脂紊乱的临床观察[J].重庆医学,2009,38(10). |
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| 作者姓名： | 白梅 任孟军 刘忠和 |
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| 作者单位： | 重庆市黔江中心医院消化内科,409000 |
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| 摘 要： | 目的 观察盐酸小檗碱(BBR)治疗非酒精性脂肪肝并血脂紊乱的的疗效与安全性.方法 47例非酒精性脂肪肝并血脂紊乱患者服用盐酸小檗碱0.5g/次,3次/天,疗程8周,治疗前后测定肝肾功能、血糖及血脂水平等指标.结果 BBR治疗后,患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)较治疗前明显下降(P<0.01),高密度脂蛋白胆固醇(HDL-C)变化不显著.血清ALT、空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)治疗后显著下降(P<0.05),而AST、TBiL及肾功Cr、BUN无明显改变.观察期间无明显不良反应.结论 BBR治疗非酒精性脂肪肝并血脂紊乱疗效确切安全,且具有降酶、降糖作用.
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| 关 键 词： | 非酒精性脂肪肝 小檗碱 血脂紊乱 |
Clinical observation on berberine treating non-alcoholic fatty liver disease |
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| BAI Mei,REN Meng-jun,LIU Zhong-he.Clinical observation on berberine treating non-alcoholic fatty liver disease[J].Chongqing Medical Journal,2009,38(10). |
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| Authors: | BAI Mei REN Meng-jun LIU Zhong-he |
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| Abstract: | Objective To evaluate the clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease(NAFLD) with dyslipidemia.Methods Forty seven patients with NAFLD and dyslipidemia were treated with berberine(1.5g daily) for 8 weeks.Before and after 8 weeks of treatment,the change of serum cholesterol(TC),triglyceride(TG),low-density lipoprotein-cholesterol(LDL-c) high-density lipoprotein-cholesterol(HDL-c),ALT,AST,TBiL,FBG,PBG,HbA1c,Cr,BUN were detected respectively.Side effect was a... |
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| Keywords: | non-alcoholic fatty liver disease berberine cholesterol triglyceride blood glucose |
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