Hepatitis C virus, an important risk factor for tuberculosis in immunocompromised: experience with kidney transplantation |
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Authors: | Juan Torres Jose María Aguado Rafael San Juan Amado Andrés Prado Sierra Francisco López-Medrano Jose María Morales |
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Institution: | Unit of Infectious Diseases and Renal Transplantation, Department of Nephrology, University Hospital "12 de Octubre", Madrid, Spain |
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Abstract: | Little is known about the role of hepatitis C virus (HCV) infection in the development of tuberculosis (TB) in patients with immunosuppression. We performed a retrospective case–control study (1:4) to investigate by univariate and multivariate logistic regression analysis the importance of HCV infection in the development of TB in a cohort of kidney transplant recipients (KTR). TB was diagnosed in 16 out of 2012 (0.8%) KTR between 1976 and 2004. The percentage of HCV-positive patients was significantly higher in cases than in controls (56.3% vs. 18.8%; P = 0.02). By multivariate analysis, the only two independent risk factors associated with the development of TB were the presence of HCV infection ( P = 0.003; OR = 6.5; 95% CI 1.9–23) and serum creatinine over 1.5 mg/dl ( P = 0.03; OR = 4.8; 95% CI 1.1–21). HCV infection and chronic graft dysfunction are important risks factors for TB in KTR. |
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Keywords: | hepatitis C virus kidney transplantation Mycobacterium tuberculosis risk factors tuberculosis |
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