| 〔~(14)C〕氨三肼(AT-1902)在小鼠体内的动态观察 |
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| 引用本文： | 王庆端,华海婴,李启韬,张覃沐,章辛,任云峰. 〔~(14)C〕氨三肼(AT-1902)在小鼠体内的动态观察[J]. 药学学报, 1989, 0(10) |
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| 作者姓名： | 王庆端 华海婴 李启韬 张覃沐 章辛 任云峰 |
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| 作者单位： | 河南省医学科学研究所药理室，河南省医学科学研究所药理室，河南省肿瘤研究所，河南省肿瘤研究所，中国科学院上海药物研究所，中国科学院上海药物研究所 郑州 450052，郑州 450052，上海 200031，上海 200031 |
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| 摘 要： | 氨三肼(AT-1902)由中国科学院上海药物研究所合成室合成。经我室实验证明,对多种动物移植性肿瘤有很强的抗肿瘤作用。本文采用整体放射自显影术,研究[~(14)C]AT-1902在动物体内的分布情况,进一步阐明分布与疗效及毒性之间的关系,为临床合理用药提供依据。
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| 关 键 词： | [~(14)C]氨三肼 放射自显影术 |
OBSERVATION ON THE DISTRIBUTION OF [~(14)C] AT-1902 IN MICE |
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| QD Wang,HY Hua,QT Li,TM Zhang,X Zhang and YF Ren. OBSERVATION ON THE DISTRIBUTION OF [~(14)C] AT-1902 IN MICE[J]. Acta pharmaceutica Sinica, 1989, 0(10) |
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| Authors: | QD Wang HY Hua QT Li TM Zhang X Zhang YF Ren |
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| Affiliation: | QD Wang,HY Hua,QT Li,TM Zhang,X Zhang~* and YF Ren~* |
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| Abstract: | Distribution of [~(14)C] AT-1902 in mice was studied by means of whole body autoradiography. After [~(14)C] AT-1902 was injected im to mice, radioactivity was rapidly taken up by various organs.The highest radioacti vity was found in kidneys, then the liver, lung, tumor and skin etc. Lowest radioactivity was found in brain. It is suggested that [~(14)C] AT-1902 may be excreted through the gastrointestinal tract and kidneys. |
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| Keywords: | [~(14)C] AT-1902 Autoradiography |
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