| 7例妇女应用布比卡因硬膜外阻滞后的药物动力学和药效学 |
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| 引用本文： | 高申,刘皋林,周自永,王世祥,陈光韫,刘树孝. 7例妇女应用布比卡因硬膜外阻滞后的药物动力学和药效学[J]. 中国新药与临床杂志, 1990, 0(2) |
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| 作者姓名： | 高申 刘皋林 周自永 王世祥 陈光韫 刘树孝 |
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| 作者单位： | 第二军医大学长海医院临床药理研究室 上海200433(高申，刘皋林，周自永，王世祥)，第二军医大学长海医院麻醉科 上海200433(陈光韫)，第二军医大学长海医院麻醉科 上海200433(刘树孝) |
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| 摘 要： | 采用HPLC法对7例妇女应用布比卡因硬膜外阻滞后的药物动力学(药动学)和药效学进行研究,数据用PKBP-N_1药动学程序包经IBM-PC计算机处理,结果符合血管外开放二室模型。T_p=19±8min;C_p=1.6±0.7μg/ml;T_((1/2)β)=166±59min;AUC=273±124μg/(min·ml);V_d=2.0±0.7L/kg。测得该药的作用完善时间和麻醉持续时间分别为21±3min和104±30min。手术期间未见明显不良反应。应用测得之药动学参数估算作用完善时和局麻持续时间的血药浓度.
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| 关 键 词： | 布比卡因 药物动力学 硬膜外麻醉 |
Pharmacokinetic and pharmacodynamic studies of bupivacaine following epidural block in seven women |
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| GAO Shen,LIU Gao-Lin,ZHOU Zi-Yong,WANG Shi-Xiang,CHEN Guang-Yun,LIU Shu-Xiao. Pharmacokinetic and pharmacodynamic studies of bupivacaine following epidural block in seven women[J]. Chinese Journal of New Drugs and Clinical Remedies, 1990, 0(2) |
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| Authors: | GAO Shen LIU Gao-Lin ZHOU Zi-Yong WANG Shi-Xiang CHEN Guang-Yun LIU Shu-Xiao |
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| Abstract: | Seven women took part in this study A dose of 2 mg/kg of bupiva-caine in a 0.5% solution was injected epidurally between 3-5 min, including a 3 ml test dose. The data, obtained from high performance liquid chromatography, were analysed with a PKBP-N,program on IBM-PC computer. An extravascular two-compartment open model was suggested with T=19- 8 min, Cp = 1.6 0.7ug/ ml, =166 59 min, AUC=273 124ug min/ml and V=2.0 0.7 L/kg. The satisfactory block effect began in 21 (3 min and lasted 104 130 min, and their plasma level were 1.6 0.8/ug/ml and 0.55 0.24ug/ml respectively. No remarkable adverse reactions were observed |
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| Keywords: | bupivacaine pharmacokinetics epidural anesthesia |
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