| 活血胶囊对绝经后骨质疏松症模型大鼠的影响 |
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| 引用本文： | 衣蕾,刘勤社,彭宁,常巧云. 活血胶囊对绝经后骨质疏松症模型大鼠的影响[J]. 中国中医药信息杂志, 2011, 18(11): 34-36. DOI: 10.3969/j.issn.1005-5304.2011.11.013 |
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| 作者姓名： | 衣蕾 刘勤社 彭宁 常巧云 |
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| 作者单位： | 陕西省人民医院,陕西西安,710068 |
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| 摘 要： | 目的观察活血胶囊对去卵巢大鼠骨质疏松症的疗效,并探讨其作用机理。方法摘除雌性Wistar大鼠双侧卵巢复制绝经后骨质疏松症模型,随机分为模型组、己烯雌酚组、活血胶囊组及假手术组。给予相应药物12周后,放射免疫法测定各组动物血清中雌二醇（E2）、促卵泡素（FSH）、促黄体生成激素（LH）水平,直接紫外法测定各组动物血清中碱性磷酸酶（ALP）、钙（Ca）、磷（P）含量,取各组动物胫骨测定骨灰重及骨Ca、P含量。结果大鼠去卵巢后血清FSH、LH、ALP、Ca、P含量显著升高,E2水平明显降低,与假手术组相比,差异有统计学意义（P〈0.05,P〈0.01）。经治疗后,活血胶囊组和己烯雌酚组大鼠血清中FSH、LH、ALP、Ca、P值水平下降,E2水平上升;骨灰重、骨Ca、骨P含量均有所升高,与模型组比较,差异有统计学意义（P〈0.05,P〈0.01）。结论活血胶囊可以通过调节雌激素水平及骨代谢达到治疗绝经后骨质疏松症的目的。
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| 关 键 词： | 活血胶囊 去卵巢大鼠 雌激素 钙 磷 绝经后骨质疏松症 |
Effect of Huoxue Capsule on Postmenopausal Osteoporosis Model Rats |
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| YI Lei,LIU Qin-she,PENG Ning,CHANG Qiao-yun. Effect of Huoxue Capsule on Postmenopausal Osteoporosis Model Rats[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2011, 18(11): 34-36. DOI: 10.3969/j.issn.1005-5304.2011.11.013 |
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| Authors: | YI Lei LIU Qin-she PENG Ning CHANG Qiao-yun |
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| Affiliation: | YI Lei,LIU Qin-she,PENG Ning,CHANG Qiao-yun(Shannxi Provincial People Hospital,Xi'an 710068,China) |
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| Abstract: | Objective To observe the efficacy of Huoxue capsule in ovariectomized rats and investigate its mechanism.Methods The female Wistar ovariectomized(OVX) rats were randomized into two groups with treatment of Huoxue capsule and Diethylstilbestrol tablets,which were compared with OVX group and pseudo-operated group.All rats were killed after giving medicine for 12 weeks.The level of E2,FSH,LH,ALP,Ca,P in serum and Ca,P in bone were determined.Results The levels of FSH,LH,ALP,Ca,P in serum of OVX rats were signi... |
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| Keywords: | Huoxue capsule ovariectomized rats female sex homone Ca P postmenopausal osteoporosis |
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