乙型肝炎病毒感染及肝硬化与结直肠癌肝转移的关系

目的探讨乙型肝炎病毒（HBV）感染和肝硬化与结直肠癌肝转移的关系。方法回顾北京大学临床肿瘤学院外科1999年1月至2004年8月收治的1176例结直肠癌患者的临床及随访资料，分析HBV感染和肝硬化对肝转移发生率及患者预后的影响。结果有和无HBV感染的两组结直肠癌患者肝转移发生率分别为8.8％（10／114）和23．9％（254／1062）。差异有统计学意义（P〈0．01）；两组患者的5年生存率分别为54．2％和60．7％．差异无统计学意义（P〉0．05）。伴和不伴肝硬化的两组结直肠癌患者肝转移发生率分别为3．8％（1／26）和22．9％（263／1150）．差异有统计学意义（P〈0．05）；两组患者5年生存率分别为60．9％和59．9％，差异无统计学意义（P〉0．05）。结论HBV感染和肝硬化可降低结直肠癌患者肝转移的发生率．但并不影响其生存率。

Association of hepatitis B virus infection and cirrhosis with liver metastasis in colorectal cancer

Objective To explore the relationship of hepatitis B virus (HBV) infection and cirrhosis with liver metastasis in colorectal cancer. Methods Clinical date of 1176 colorectal cancer patients undergone surgical treatment in the Peking University School of Oncology between January 1999 and August 2004 were analyzed retrospectively to investigate the impact of HBV infection and cirrhosis on the occurrence of liver metastasis and prognosis of patients. Results The incidence of liver metastasis was 8.8% (10/114) in the HBV infection group and 23.9% (254/1062) in the non-infection group(P<0.01). The 5-year survival rates of these two groups were 54.2% and 60.7%(P>0.05). The incidence of liver metastasis was 3.8%(1/26) in the cirrhotic group and 22.9%(263/1150)in the non-cirrhotic group (P<0.05). The 5-year survival rotes of these two groups were 60.9% and 59.9%(P>0.05). Conclusion Both hepatitis B vires infection and cirrhosis are associated with less liver metastasis in colorectal cancer, but have no impact on the survival.